Objectives: This study was planned to evaluate the efficiency and safety of Intratympanic (IT) injection of methylprednisolone (IT-MP) on idiopathic sudden sensorineural hearing loss (ISSHL) patients as an initial therapy, by weighing against the outcome with intravenously administered dexamethasone (IVDEX) treatment. Materials and Methods: A prospective, nonrandomized, comparative study was co...

OBJECTIVE Intratympanic steroids are increasingly used in the treatment of inner ear disorders, especially in patients with sudden sensorineural hearing loss (SNHL) who have failed systemic therapy. We reviewed our experience with intratympanic steroids in the treatment of patients with sudden SNHL to determine overall success, morbidity, and prognostic factors. HYPOTHESIS Intratympanic stero...

BACKGROUND Ménière's disease is a disorder characterised by hearing loss, tinnitus and disabling vertigo. The use of intratympanic steroids to reduce the severity of these symptoms has been gaining popularity. OBJECTIVES To assess the effectiveness of intratympanic steroids on the frequency and severity of attacks of vertigo, on chronic symptoms such as tinnitus, imbalance and hearing loss, a...

The otoprotective effects of OTO-104 were investigated following both acute and chronic administration of cisplatin. The acute administration of cisplatin to guinea pigs resulted in profound hearing loss (70-80 dB SPL) across all frequencies tested. A single intratympanic injection of 6% OTO-104, but not of lower doses, almost completely protected against cisplatin ototoxicity. In contrast, a d...

OBJECTIVE The study aimed to assess the possible systemic effects of intratympanic dexamethasone (IT-Dex) on the hypothalamic-pituitary-adrenal (HPA) axis, inflammation, and bone metabolism. DESIGN A prospective cohort study including 30 adult patients of a tertiary referral ENT clinic treated with 9.6 mg IT-Dex over a period of 10 days was carried out. METHODS Effects on plasma and salivar...

Drop attack (DA) associated with Ménière's disease (MD) and delayed endolymphatic hydrops (DEH) is not common and may cause life-threatening clinical problems. The intratympanic dexamethasone (ITD) is one of primary treatments for MD or DEH. Our study investigated the effect of ITD on the DA associated with endolymphatic hydrops (EH).We retrospectively reviewed 10 patients with MD- and DEH-asso...

Objective: To evaluate vertigo control and auditory rescue in patients with Meniere's disease treated intratympanic Gentamicin Dexamethasone.
 Study Design: Randomized Control Trial (Clinical Trials. gov Identifier: NCT05355610).Place Duration of Study: ENT Departments CMH Quetta Benazir Bhutto Hospital Rawalpindi Pakistan from Apr 2020 to Mar 2022.
 Methodology: Ninety-three cases un...

Introduction: Meniere’s disease (MD) is a disease of the inner ear that presents itself with repeated episodes of vertigo (96.2%), tinnitus (91.1%), and sensorineural hearing loss (87.7 %). In this article we sought to assess the effects of intratympanic (IT) injections of dexamethasone on definite cases of MD using electrocochleography (ECOG). Materials and Methods: In this hospital-based case...

Introduction The study aims to determine the role of intratympanic dexamethasone (ITD) on hearing profile patients with head and neck cancer post-chemoradiotherapy. Study design This employs a prospective case-control design. Subjects methods In total 834 were evaluated for eligibility. Seven hundred eleven excluded because they didn’t meet inclusion criteria. A cases out 123 diagnosed which tr...