We investigated, in a double-blind study, the effects of intraperitoneal local anesthetics during laparoscopic cholecystectomy. In Part A of the study 30 patients received 50 mL saline 0.9% (A 0), bupivacaine 0.125% (A 125), or bupivacaine 0.25% (A 25) intraperitoneally at the end of surgery. Mean maximum plasma concentrations of bupivacaine reached 0.48 mg/L (range 0.15-0.90 mg/L) in Group A 1...

PURPOSE To study the analgesic efficacy of intraperitoneal and periportal injection of bupivacaine following laparoscopic cholecystectomy. MATERIALS AND METHODS 40 patients undergoing laparoscopic cholecystectomy were randomized into two groups of 20 each. Group A (study group) received 40 ml of intraperitoneal injection of 0.25% bupivacaine and 20 ml of same concentration in 4 ports, 5 ml ea...

Objectives: The aim of this study was to assess the analgesic efficacy of Bupivacaine application at port-site and intraperitoneal infiltration in patients with laparoscopic cholecystectomy. Study Design: Randomized Controlled Clinical Trial. Place and Duration: The study was conducted at Rehman Medical Institute (RMI) Peshawar, Pakistan from June 2009 to June 2012. Materials and Methods: Patie...

BACKGROUND Pain following laparoscopy could be due to different causes requiring effective postoperative analgesia. OBJECTIVES In the present study, we evaluated the combined effect of intraperitoneal infiltration of bupivacaine-meperidine versus intravenous infusion of paracetamol on pain relief after diagnostic gynecologic laparoscopy. PATIENTS AND METHODS In this prospective study, 90 fe...

Aim: To compare the effectiveness of 0.5% bupivacaine spray on gallbladder at end surgery with no in reducing postoperative pain within first 24 hours. Study design: Randomized Controlled Trial Place and duration: The study was conducted Department General Surge,Combined Military Hospital, Rawalpindi, from 23 July 2018 to 22 January 2019, after receiving approval ethics review board. Method: A ...

the purpose of this study was to compare the effect of intraperitoneal bupivacaine and lidocaine administration on pain reduction after diagnostic laparoscopy. in this randomized, double blind, placebo controlled study, diagnostic laparoscopy was done for one-hundred and ninety-six infertile women with unexplained infertility. patients were randomized to 4 groups (a, b,c, and d). at the end of ...

OBJECTIVE To evaluate the efficacy of combined infiltrative bupivacaine with low intraperitoneal pressure insufflation in reducing the post-laparoscopic pain in patients undergoing laparoscopic cholecystectomy (LC). METHODS This randomized prospective single-blind study included 473 patients undergoing LC. The study took place at University Hospital Center Mother Teresa, Tirana, Albania betw...

The purpose of this study was to compare the effect of intraperitoneal bupivacaine and lidocaine administration on pain reduction after diagnostic laparoscopy. In this randomized, double blind, placebo controlled study, diagnostic laparoscopy was done for one-hundred and ninety-six infertile women with unexplained infertility. Patients were randomized to 4 groups (A, B,C, and D). At the en...