The evaluation of intraocular tumors differs from almost all other oncologic evaluations because there is little reliance on tissue diagnosis. Definitive therapies such as enucleation and radiation are usually based on the results of ophthalmoscopy and a limited number of ancillary studies without the aid of biopsy. Although biopsies can be performed on most intraocular tumors, the ocular morbi...

fusion for retinoblastoma. Doc Ophthalmol. 2009; 119(1):13-22. 3. Reese AB, Hyman G, Tapley N, Forrest AW. The treatment of retinoblastoma by x-ray and triethylene melamine. AMA Arch Ophthalmol. 1958; 60(5):897-906. 4. Mohri M. The technique of selective ophthalmic arterial infusion for conservative treatment of recurrent retinoblastoma [in Japanese]. Keio J Med. 1993;70:679-687. 5. Yamane T, K...

The eye is normally an immunosuppressive environment. This condition is better known as immune privilege and protects the eye from immune-mediated inflammation of tissues that cannot regenerate. However, immune privilege creates a dilemma for the eye when intraocular neoplasms arise. In some cases, immune privilege is suspended, resulting in the immune rejection of intraocular tumors. This stud...

Allogeneic tumors, transplanted into the anterior chamber of the mouse eye, grow progressively and eventually kill the host. However, recipients that have been previously immunized to the alloantigens of the tumor are completely resistant to intracameral tumor challenge. In the present study the authors examined the role of specific immune effector elements in preventing, controlling, or eradic...

Interference of oncogenic N-nitrosourea in intraocular tumor induction by human adenovirus type 12 in rats was examined. Transplacental administration of methylnitrosourea to rat embryo reduced significantly the latent period of the intraocular adenovirus tumor in each animal whereas in groups preadministered with ethylnitrosourea the decrease in the latent period showed marked individual varia...

The role of the immune response in the elimination of spontaneous metastases arising from intraocular tumors was examined in a syngeneic intraocular murine tumor model. P91 mastocytoma (DBA/2 origin) expresses strong tumor-specific transplantation antigens and grows transiently in the eyes of syngeneic hosts before undergoing spontaneous rejection. An organ culture technique was used to detect ...

background: fine-needle aspiration cytology (fnac) is used for diagnosis of intraocular, orbital and eyelid lesions. in this study we evaluated the outcome and the accuracy of using this technique in diagnosis of benign or malignant behavior of lesions.   methods: fnac was performed on 26 specimens obtained from 25 patients with intraocular, orbital and eyelid tumors and the results were compar...

PURPOSE To describe clinical, optical coherence tomography (OCT) and fundus autofluorescence (FAF) findings in patients with intraocular tumors and determine if OCT and FAF could be helpful in the differential diagnosis and management of different choroidal tumors. METHODS Forty-nine patients with untreated, macular, midperipheral, and extrapapillary intraocular tumors were included. All pati...

Background and Aims: Retinoblastoma tumors are the most common intraocular malignancy in childhood, leading to death after two years. The Human Adenovirus (HAdV) infection could be critical in the retinoblastoma pathogenesis due to the virus and retinoblastoma 1 interactions. The objective of the current study was to investigate the possible presence of the HAdV genome in the retinoblastoma pat...