OBJECTIVE To compare the clinical efficacy of methotrexate and tolerance to the drug in patients with rheumatoid arthritis who were switched from intramuscular to oral administration because of a shortage of the intramuscular preparation. METHODS 143 patients were switched from intramuscular to oral methotrexate. Of these, 47 were switched back to the intramuscular form. A multiple choice que...

Pharmacokinetics of ceftriaxone was studied in buffalo calves (Bubalus bubalis) after single intravenousand intramuscular administration of 10 mg/kg body weight. The drug concentrations in plasma samples weremeasured by high performance liquid chromatography with UV detection. Following intravenousadministration, the drug was rapidly distributed (Cpo: 106.5 ± 9.64 μg/ml; t1/2α: 0.09 ± 0.01 h; V...

The pharmacokinetics of levofloxacin following its single intramuscular administration (3 mg/kg) was investigated in six male buffalo calves. Peak plasma level of 2.95 ± 0.13μg/ml was observed at 1 h and the drug level above MIC90  in plasma was detected up to 12 h of administration. The bioavailability was 68.1 ± 5.4% and levofloxacin was bound to the plasma proteins to the extent of 19.1 ± 1....

Oral administration of aureomycin is currently the method of choice. The intravenous route is occasionally used when oral administration becomes difficult by reason of excessive nausea, vomiting, or diarrhea. The intramuscular injection of aureomycin is now but little used since early reports by some workers indicated that blood levels obtained by this route were relatively low, and, more impor...

To the Editor—As a reader of Clinical Infectious Diseases living and working in Vietnam, I was naturally drawn to the article by Murray et al. [1] about infections during the Vietnam-America conflict. I was, however, disappointed to see the expression “the global war on terrorism” appear twice in the article. “The global war on terrorism” is a doctrinal slogan that may be popular in the United ...

The pharmacokinetic studies of enrofloxacin were investigated in yak (Bos grunniens L.) after administration of enrofloxacin by intramuscular route at 5 mgkg-1 body weight. Blood samples were collected from the jugular vein at predetermined time intervals after drug administration. Plasma was separated and analysed for enrofloxacin by reverse-phase high performance liquid chromatography. Variou...

In circumstances such as in vitro fertilization (IVF) or in patients with luteal phase defect, one needs to ensure the establishment of pregnancy as soon as possible. At the same time, a question arises: How can a physician make sure that the β-hCG is of an endogenous source and not the residue of the prescribed drugs (hCG)? In this article we have studied the elimination time of 1M inject...

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