objective to determine the role of ketogenic diet in the treatment of intractable epilepsy in children. materials & methods sixty six consecutive children (1-16 years old) with intractable epilepsy whose seizure were not neurodegenerative nor febrile in origin were recruited. they received the ketogenic diet and we evaluated its effect on seizure frequency for 3 months. all these children had m...

Epilepsy is a chronic disease affects CNS in various ages. WHO estimates 50 million people are suffering from epilepsy worldwide which make it a serious prevalent problem among neurological diseases. Intractable epilepsy (IE) affects about 20-30% of epileptic patients who failed to be seizure - free after antiepileptic drug (AED) consumption. Although many AEDs now are available for epilepsy tr...

AIM In this retrospective study, we evaluated the clinical responses to antiepileptic drug (AED) therapy in pediatric epilepsy patients treated at a single center. MATERIALS AND METHODS We identified 28 children with intractable epilepsy and 213 patients with drug-responsive epilepsy. RESULTS Univariate analysis showed that age at onset, high (daily) initial seizure frequency, infantile spa...

OBJECTIVE Trace elements such as zinc and copper have physiological effects on neuronal excitability that may play a role in the etiology of intractable epilepsy. This topic has been rarely discussed in Iranian epileptic patients. This study with the analysis of serum zinc and copper levels of children and adolescents with intractable and controlled epilepsy may identifies the potential role of...

objective 1-3% of the population suffer from epilepsy. up to 30% of them develop refractory epilepsy and their seizures occur more than once per month despite receiving at least 2 first line antiepileptic drugs. in  this group, more efficacious antiepileptics are needed. this study was undertaken to evaluate the efficacy and safety of oxcarbazepine as an adjunction therapy in children with refr...

Corresponding Author: J. Akhondian MD Ghaem Medical Center,Mashad,Iran Tel: +98 511 8012469 Fax: +98 511 8417451 Email: [email protected] Abstract Objective Epilepsy is a common disorder affecting approximately 1% of the population. It is estimated that about 2030% of the patients become refractory to proper medical therapies. Such cases are often termed intractable. Intractable epilepsy (I...

PURPOSE Intractable epilepsy is a brain disorder characterized by recurrent seizures and intracellular alpha-synuclein (αS) deposits; however, the neurobiological basis of this protein accumulation is still poorly understood. This is the first study aiming to assess whether the increase of αS concentrations in the serum and CSF (cerebrospinal fluid) could serve as a marker for αS deposition in ...