OBJECTIVE To determine the preventive effects of local administration of simvastatin for postoperative intra-abdominal adhesion formation in animal model of rat. METHODS In this experimental study, 32 Wistar albino rats as the animal model of intra-abdominal adhesion formation were included. Adhesions were induced in all the animals via abrasion of the peritoneal and intestinal surface during...

laparoscopic technique in recent years has tremendously being used as a non invasive surgery to perform different operation in abdominal and thoracic cavities. this technique has been used from 1987 in different aspect of human surgery. in addition to diagnosis, biopsy, visualizing adhesion and neoplastic structure, recently cholecystectomy and ovariohysterectomy were also commonly being used a...

Objective(s)The purpose of this study holds, for the first time, an evaluation of the intraperitoneal curcumin lavage on the development of post-operative intra-abdominal adhesions.Materials and MethodsThirty male Wistar rats were randomized into five groups. The rats were administered anesthesia and underwent surgery in order to create intra-abdominal adhesions. Before the abdomen was closed, ...

peritoneal adhesions are challenging in abdominal surgery. in spite of different kinds of treatments still no definitive and effective treatment is suggested. to determine the prevention effects of intraperitoneal (ip) methylene blue in post surgical adhesion formation 44 rabbits were randomly divided in two groups of equal number. group i received an intra peritoneal injection of a 1% suspensi...

since co2 pneumoperitoneum is the dominant method of laparoscopic exposure due to facility and good view, its physiologic effects are most relevant to the surgeons. co2 pneumoperitoneum may affects hemodynamics by increased intra-abdominal pressure (iap) and the physiologic effects of absorbed co2. the adverse effects of both mechanisms relate directly to the duration of the pneumoperitoneum an...

abdominal wall hernias are common problems found in patients with cirrhosis because of persistently high intra-abdominal pressure. when abdominal hernias are neglected in such patients, they may become larger and could result in cosmetic problems and pressure effects that are also difficult to treat. we found a voluminous mass in the anterior abdominal wall of a 40-year-old patient with cirrhos...

Methods Forty female BALB/c mice were randomly assigned into 2 groups. The mice were anesthetized and then midline abdominal incision was made. Peritoneal injury was given using cytobrush until deperitonealization. The experimental group (n = 20) received NF-κB decoy oligodeoxynucleotide (NF-κB decoy ODN) in the peritoneal cavity before abdominal closure, while the control group (n = 20) receiv...

Background: Postoperative peritoneal adhesion bands are one of the most common complications caused by foreign material.  Objective: To investigate the effect of colchicine on talc-induced peritoneal adhesion bands. Method: Adhesion bands were induced in 30 short hair England Guinea pigs by introduction of talc-saline solution (10 mL, 10%) into the peritoneal cavity.  Afterwards, the pigs were ...