The pathogenesis of pulmonary veno-occlusive disease (PVOD) is not known. The diagnosis of PVOD frequently relies on its histological changes since it is often difficult to distinguish clinically from primary pulmonary hypertension. This study carried out a systematic analysis of the pulmonary venous and arterial remodelling that occurs in PVOD (n=5) and compared these changes to two other dise...

BACKGROUND Atherosclerotic plaque progression is frequently accompanied by compensatory enlargement to preserve the lumen. These enlarging plaques develop features of vulnerability, however, leading to disruption and lumen obstruction. This complex transition from compensatory expansion to plaque disruption may not derive solely from progressive intimal disease. Concurrent changes at the intimo...

A 47-year-old man presented with sudden-onset headache and Fisher group 3 subarachnoid hemorrhage. The World Federation of Neurological Surgeons grade was II. Digital subtraction angiography (DSA) only showed a vessel wall irregularity in the A1 segment right anterior cerebral artery (ACA), but an obvious bleeding source not detected. Repeat tiny aneurysmal dilatation intimal flap. aneurysm enl...

Perivascular administration has attracted increasing attention since intimal hyperplasia was identified as the main cause for coronary and peripheral bypass graft occlusion. For preventing the graft occlusion, a local treatment using a sustained drug delivery system would be ideal, as the vessels are readily exposed to the vascular surgeons [1]. However, neither local nor oral formulations have...

Aortic dissections that originate from isolated tears in the abdominal aorta are uncommon. Rarer still are cases of isolated abdominal aortic dissections arising in suprarenal locations, as most appear from infrarenal intimal defects. We present a quite unusual case of a spontaneous supraceliac isolated abdominal aortic dissection sparing the renal and mesenteric arteries and manifesting as chr...

INTRODUCTION Atherosclerotic coronary artery thrombosis is the most common cause of acute myocardial infarction. CLINICAL PICTURE A 30-year-old lady presented with acute peripartum massive anterior ST segment myocardial infarction and cardiogenic shock. This was due to acute Stanford type A aortic dissection with the intimal flap occluding the left coronary ostium. The initial diagnosis was n...

Malfunction of a prosthetic aortic valve is associated with a spectrum of potentially life threatening complications. In addition, the risk of aortic dissection increases following aortic valve replacement, which relates principally to aortic root pathology rather than prosthetic type or its functional status (Circulation 100 (1999) II-287). We report a case in which a high velocity turbulent j...

A widely adopted surrogate for predicting rates of cardiovascular events involves measure of carotid intimal-medial thickness (CIMT) by B mode ultrasound, a technique available since the mid 1980s. The value of this modality remains in its ability to noninvasively assess cardiovascular risk beyond traditional factors identified by the Framingham risk score, and it is among the few available tec...

A widely adopted surrogate for predicting rates of cardiovascular events involves measure of carotid intimal-medial thickness (CIMT) by B mode ultrasound, a technique available since the mid 1980s. The value of this modality remains in its ability to noninvasively assess cardiovascular risk beyond traditional factors identified by the Framingham risk score, and it is among the few available tec...

Correction of errors and misleading data is an educational precept, and Weller's misconception of cerebral (berry) aneurysm pathology 1 is a case in point. His illustration of their frequency distribution depicts basilar aneu-rysms arising from the crotch but other aneu-rysms arising at lateral angles of forks or junctions. Though this was perhaps inadvertent , it is grossly misleading: such lo...