BACKGROUND Optical coherence tomography (OCT) is a high-resolution intravascular imaging technique used in adults. We tested the hypothesis that OCT could identify coronary abnormalities not seen by angiography in children with a history of Kawasaki disease (KD) and pediatric heart transplant (TX) recipients. METHODS AND RESULTS Patients with KD and TX recipients were evaluated between Decemb...

Intravascular ultrasound (IVUS) imaging was performed to assess the coronary wall morphology in detail at 22 months after the onset of Kawasaki disease in a girl who had developed coronary aneurysms at 4 yr of age. The sites of persistent aneurysms demonstrated a dilated lumen with a marked symmetrical or asymmetrical thickening of the intima-media complex. This pathologic finding was also pres...

BACKGROUND The present study was designed to characterize early structural changes of large arteries in renal transplant recipients with no clinical evidence of cardiovascular disease and normal blood pressure values, and to analyse the relationship between arterial alterations and those of the heart. METHODS Intima media thickness and atherosclerotic plaques of the carotid arteries as well a...

To evaluate ultrasonographically determined intima-media thickness as a measure of early atherosclerosis, three studies were performed. Ultrasound measurements of intimamedia thickness in the carotid artery were directly validated by comparing the same thickness measured by light microscopy. The values were closely correlated (r=.82, P<.001). Intima-media thickness determined by light microscop...

120 COMMUNICATIONSTO THE EDITOR CHEST, 78: 1, JULY, 1980 ly out of the neck-and-sternal incision and the patient died within minutes. Autopsy disclosed an aneurysmal dilatation of the ascending aorta, with a 2 cm transverse irregular tear on its posterior aspect, 4 cm from the aortic valve. In the intima, the tear extended to 6 cm length (Fig 1). Microscopic examination of the aortic arch showe...

The effect of diabetic metabolism on the human vascular wall studied, using the fetal cardiovascular system at birth as an experimental model. The ultrastructure of umbilical arteries from nine newborn children of nonsmoking diabetic mothers (White group D) was compared with that of 30 healthy nonsmokers. Intimal cushions, thickening of the basement membrane often with a multilaminal appearance...

Atherosclerosis is a generalized disease causes thickening of arterial wall which leads to cardio-vascular disease. Automatic algorithm for measurement of Intima Media Thickness (IMT) in B-mode in ultrasound video frames is developed. Different types of despeckling filters are used to reduce granular noise and evaluated. As well as textural features are extracted from original and despeckled im...

Angiotensin II and the arachidonic acid metabolite derived via cytochrome P450 20-hydroxyeicostetraenoic acid promote vasoconstriction and vascular smooth muscle cell (VSMC) proliferation. This study was conducted to determine if 20-hydroxyeicostetraenoic acid contributes to angiotensin II-induced neointimal formation in balloon-injured rat carotid artery. In anesthetized rats, the drugs were i...