ture was referred by the orthopedic department at our hospital for severe hypoproteinemia. The patient had been diagnosed as having primary intestinal lymphangiectasia at the age of 25. Under capsule endoscopy, numerous filiformlike polyps with whitish villi were observed from the distal duodenum to the jejunum (●" Fig. 1a) with exudation of a chylous substance from the mucosal surface (●" Fig....

Mutations in the adenomatous polyposis coli gene or activating mutations in the beta-catenin gene itself are thought to be responsible for the excessive beta-catenin signaling involved in intestinal carcinogenesis. We generated transgenic mice that expressed large amounts of a NH2-terminally truncated mutant beta-catenin (deltaN131beta-catenin) in the intestine. These mice had multifocal dyspla...

Cyclooxygenase-2 (COX-2), the inducible COX isozyme, plays a key role in intestinal tumorigenesis. We have demonstrated recently that COX-2 protein is induced in the polyp stroma near the intestinal luminal surface in the Apc(Delta716) mouse, a model for human familial adenomatous polyposis, and stimulate tumor angiogenesis. However, the precise cell types that express COX-2 are still to be det...

IN 1921 Peutz described a family with intestinal polyposis and spots of melanin pigmentation in and around the mouth. Prior to this, in 1896, Sir Jonathan Hutchinson described two girls with pigmented patches in the oral mucosa and around the mouth. Later, Parkes Weber (1919) reported that one of these twins died of what appeared to be an intussusception. Since 1921 over one hundred cases have ...

INTRODUCTION Peutz-Jeghers Syndrome (PJS) is an uncommon autosomal dominant hamartomatous polyposis syndrome. Morbidity arises from polyp-related complications and increased risks of malignancy. We report on PJS patients registered in the Singapore Polyposis Registry, identified principal causes of morbidity and appraised current management strategies. A followup protocol based on recent litera...

Analysis of two human familial cancer syndromes, hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis, indicates that mutations in either one of four DNA mismatch repair gene homologues or the adenomatous polyposis coli (APC) gene, respectively, are important for the development of colorectal cancer. To further investigate the role of DNA mismatch repair in intestinal tu...

Analysis of two human familial cancer syndromes, hereditary nonpol yposis colorectal cancer and familial adenomatous polyposis, indicates that mutations in either one of four DNA mismatch repair gene homo logues or the adenomatous polyposis coli (APC) gene, respectively, are important for the development of colorectal cancer. To further investigate the role of DNA mismatch repair in intestinal ...

INTRODUCTION: Peutz-Jeghers syndrome (PJS) is a rare (orphan) hereditary disease with family history, primarily characterized by massive polyposis of the gastrointestinal tract and its complications. Every year, registered in 1 patient per 25,000–300,000 population. OBJECTIVE: To demonstrate effectiveness combined use diagnostic radiology endoscopic imaging techniques diagnosis this A case repo...