We report an extremely rare case of small intestinal cancer metastasized to the urinary bladder, presenting a urologic symptom. A 41-year-old man first presented with nausea, vomiting and abdominal pain. Based on the clinical diagnosis of jejunal cancer, he underwent a partial resection of the jejunum with lymph node dissection. The pathological diagnosis was moderately differentiated adenocarc...

Preoperative imatinib therapy has been recommended as a safe and efficient approach for unresectable local advanced gastrointestinal stromal tumors (GISTs) regardless of synchronous metastasis or not. However, whether different primary sites would impact the efficacy duration time preoperative was still under exploration. Besides, it unclear about effect on surgical outcomes prognosis. We retro...

Gastrointestinal stromal tumors (GISTs) are the common neoplasms of the gastrointestinal (GI) tract. Liver and peritoneum are the most metastatic sites, but lymph node metastasis is relatively rare. In this study, 6 cases of GISTs with lymph node metastasis were studied and reviewed the literature. The patients (5 males and 1 female) ranged in age from 48 to 75 years (median, 66 y). Primary tum...

Our study investigated the relationship between MYC alterations and clinicopathological features in gastric cancers. We evaluated the effect of MYC mRNA expression and its protein immunoreactivity, as well as copy number variation, promoter DNA methylation, and point mutations, in 125 gastric adenocarcinoma and 67 paried non-neoplastic tissues. We observed that 77% of the tumors presented MYC i...

BACKGROUND Oncogenic Bmi-1 (B-lymphoma Moloney murine leukemia virus insertion region-1) belongs to the Polycomb-group (PcG) family of proteins and plays an important role in the regulation of proliferation, senescence, cell cycle and apoptosis, chromosome stability, activation of gene transcription. METHODS To clarify the roles of Bmi-1 in tumourigenesis and progression of gastric carcinomas...