A simplified finite element model of the human lumbar intervertebral disc was utilized for understanding nucleus pulposus implant mechanics. The model was used to assess the effect of nucleus implant parameter variations on the resulting compressive biomechanics of the lumbar anterior column unit. The effects of nucleus implant material (modulus and Poisson's ratio) and geometrical (height and ...

Background: lumbar disc degeneration is a multifactorial degenerative disease which is affected by genetic inheritance and environmental factors. Type XI collagen is important for organization of the extracellular matrix and cartilage collagen construction. Rs1676486 is a SNP that causes the conversion of C-T, resulting in a change in the expression of the collagen 11 alpha chain. The T allele ...

background: a large proportion of patients presenting with lumbar disc disease are opium addicts in our region. it was, therefore, hypothesized that morphine might affect the intervertebral disc. we investigated the histological findings of morphine dependency on intervertebral discs in rat.   methods: forty nmri adult male rats (230-250 g) placed on ordinary diet and received aqueous solution ...

background: intervertebral disc herniation is a major cause of low back pain. several treatment methods are available for lumbar disc herniation including chemonucleolysis, open surgery, nucleoplasty, laser disc decompression, and intradiscal electrothermal therapy. the high prevalence of lumbar disc herniation necessitates a minimally invasive yet effective treatment method. in this study, we ...

Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity. Degeneration of the disc can be a normal process of ageing, but can also be precipitated by other factors. Literature has made substantial progress in understanding the biological basis of intervertebral disc, which is reviewed here. Current medic...

Introduction: Disc degeneration is a natural aging process characterized by changes in appearance and chemical structure of the disc. This degeneration leads to back pain. In regard to the limitation of current therapeutical methods for patients with degenerated discs, arthroplasty has been suggested as an alternative method. To manufacture artificial discs for Iranians, determining normal lumb...

INTRODUCTION Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between the nucleus and the annulus, signal intensity and intervertebral disc height. The lack of a continuous measure has made it difficult to sensitively examine degenerative disc ...

introduction: due to limitations of current treatments for degenerative disc disease, arthroplastic methods to repair the diseased disc have been proposed. the artificial disc is a mobile implant for degenerative disc replacement that attempts to lessen the degeneration of the adjacent elements following interbody fusion procedures. because the success of artificial disc replacement depends on ...

BACKGROUND Although thoracic vertebral malformations with kyphosis and scoliosis are often considered incidental findings on diagnostic imaging studies of screw-tailed brachycephalic breeds, they have been suggested to interfere with spinal biomechanics and intervertebral disc degeneration. It is however unknown if an abnormal spinal curvature also predisposes dogs to develop clinically relevan...