We have identified a unique human microtubule-associated protein (MAP) named ASAP for ASter-Associated Protein. ASAP localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis and directly binds to purified microtubules by its COOH-terminal domain. Overexpression of ASAP induces profound bundling of cytoplasmic m...

introduction: the formalin test is the most accepted chemical test for evaluation of nociception. it requires the injection of an adequate amount of formalin into the surface of the hindpaw. formalin test consists of phase 1 (0-7 min) and phase 2 (15-60) in which the animal shows painful behaviors. these phases are separated with a quiet phase named interphase, in which the nociceptive response...

portion of the cytoplasm and resulted in a continual, circling motion around a central cell mass. Special aspects of the stream ing were the relatively constant cycling time of 1 min, the gel-sol interphase appearance, reversal of direction, the occurrence of exactly proportioned biphasic forms, and the invariable presence of cohesion loss and cell rounding. The initiation of the move ment, the...

background: exposure to ionizing radiation results in genotoxicity and the unrepaired lesions in cellular dna results in cell cycle arrest, reproductive death, interphase death, division delay, chromosome aberrations, mutations, etc. leading to the intensive destruction of cells and violation of their proliferative capacity there by adversely affecting the mammalian system. since ionizing radia...

Introduction: The formalin test is the most accepted chemical test for evaluation of nociception. It requires the injection of an adequate amount of formalin into the surface of the hindpaw. Formalin test consists of phase 1 (0-7 min) and phase 2 (15-60) in which the animal shows painful behaviors. These phases are separated with a quiet phase named interphase, in which the nociceptive respon...

as “radiomimetic― because, like X-rays, these agents give rise to mitotic death (7) ; that is, dividing cells are “steri lized―in the sense that they are prevented from undergoing indefinite duplication, and an individual cell loses the ca pacity to form a clone. After sustaining a lethal injury, defined as an injury causing inability to form a clone, cells may divide several times and ...

as “radiomimetic― because, like X-rays, these agents give rise to mitotic death (7) ; that is, dividing cells are “steri lized―in the sense that they are prevented from undergoing indefinite duplication, and an individual cell loses the ca pacity to form a clone. After sustaining a lethal injury, defined as an injury causing inability to form a clone, cells may divide several times and ...

In this work, the Z interphase parameter which determines the tensile strength of interphase layers in polymer nanocomposites is presented as a function of various material and interphase properties. In this regard, the simple Pukanszky model for tensile strength of polymer nanocomposites is applied and the dependency of Z to different characteristics of constituents and interphase are illustra...