To compare the number of tumors per eye for mosaic carriers RB1 pathogenic variants with full germline and conversion from unilateral to bilateral disease. Retrospective cohort study comparing patients retinoblastoma different genetic subtypes: high penetrance (HP), low (LP), mosaicism. Data were analyzed between 1992 2018 at Retinoblastoma Unit, Royal London Hospital, London, United Kingdom. A...

Retinoblastoma is the most common intraocular malignancy. Its incidence has been reported to be 1 case in from 15 000 18 live births, or approximately 12, 6, 4 cases per million children younger than 5, 10, years, respectively.1,2 The aim of this study was estimate retinoblastoma across European countries within a 1-year time frame. Data were collected through an international, multicenter, cro...

BACKGROUND Intra-arterial administration of melphalan chemotherapy has shown promise in the treatment of retinoblastoma. This report describes our results using superselective intra-arterial melphalan in patients with newly diagnosed retinoblastoma and those who were treated for progression after systemic chemotherapy. METHODS This is a retrospective review of all retinoblastoma patients trea...

IMPORTANCE Anterior chamber seeding following intraophthalmic artery chemotherapy is rarely reported. OBJECTIVES To describe clinicopathologic observations in eyes in which intraophthalmic artery chemotherapy for retinoblastoma failed and to report anterior chamber involvement. OBSERVATIONS A retrospective case series of 12 enucleated eyes (11 patients) with retinoblastoma refractory to int...

BACKGROUND Retinoblastoma is considered the most common intraocular malignancy in childhood, comprising 4% of all pediatric cancers. Management of retinoblastoma has evolved over the past two decades and intra-ophthalmic artery chemotherapy has emerged as a new modality of globe-conserving treatment with excellent results. This treatment achieves effective tumor reduction by delivering localize...

PURPOSE To determine ocular survival and factors affecting globe survival in patients diagnosed with retinoblastoma at King Hussein Cancer Center (KHCC). METHODS A retrospective review of medical records of 71 Jordanian patients (45 males and 26 females) diagnosed with retinoblastoma (114 eyes) between June 2003 and May 2013 was conducted. Patient sociodemographic and relevant characteristics...

purpose : to introduce a novel classification system for the extent of choroid invasion and to analyze the incidence of histopathologic risk factors (hrfs) in the patients with retinoblastoma in china methods : the clinical data of 104 enucleated eyes diagnosed with retinoblastoma were retrospectively reviewed, and the pathological re-examination of the enucleated eyes was conducted. results : ...

Background and Aims: Retinoblastoma tumors are the most common intraocular malignancy in childhood, leading to death after two years. The Human Adenovirus (HAdV) infection could be critical in the retinoblastoma pathogenesis due to the virus and retinoblastoma 1 interactions. The objective of the current study was to investigate the possible presence of the HAdV genome in the retinoblastoma pat...