Reinforcement learning (RL) research typically develops algorithms for helping an RL agent best achieve its goals—however they came to be defined—while ignoring the relationship of those goals to the goals of the agent designer. We extend agent design to include the meta-optimization problem of selecting internal agent goals (rewards) which optimize the designer’s goals. Our claim is that well-...

benzoyl peroxide (bpo) is a first-line topical treatment in acne vulgaris, and it is superior to antibiotics, because the bacteria do not develop resistance to it. skin irritation is a common side effect, and it has been shown that controlled release of bpo from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. therefore, the purpose of the pres...

We prepared the poly(succinimide) (hereafter abbreviated as PSI) microcapsules with antitumor agent showing a pH-responsive release. PSI microcapsules enclosing Irinotecan hydrochloride (CPT-11) were prepared by solvent evaporation method via O/O emulsion system. The obtained PSI microcapsules had a smooth surface and were spherical with diameter of approximately 30 μm. CPT-11 was successfully ...

The Earth’s surface processes are predominantly controlled by the interaction between the Earth’s internal heat and solar radiation. Surface heat-flow measurements reflect the increase in temperature with depth, which results in flow of the Earth’s internal heat from the core, through the mantle, to the surface. Heat-flow is highest in volcanically active regions and is lowest near oceanic tren...

According to the composition of substances, release agent can be divided into organic and inorganic two types, includes mica powder, graphite etc., mainly silicon, fluorin. service life, one-time semi-permanent agent. This paper introduced several kinds releasing agent, summarized analyzed advantages present situation domestic foreign research, prospected future

The aim of the present study was to formulate and investigate the calcium alginate- (CA-) Neusilin US2 nanocomposite microbeads containing preconcentrate of aceclofenac sodium (ACF-Na) liquid microemulsion (L-ME) for enhancement of oral bioavailability. The preconcentrate L-ME is prepared by using Labrafac PG, Labrasol, and Span 80 as oil, surfactant, and cosurfactant, respectively. The solid C...

      Hard gelatin capsule filled with acetaminophen, osmotic agent (sorbitol), a release promoter (sodium dodecyl sulfate), coated with a semipermeable cellulose acetate membrane containing a hydrophobic plasticizer (castor oil) and sealed with white bees wax plug was designed. When placed in the sink water penetrates the membrane, dissolves the osmotic agent and increases the osmotic pressure...

the aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, salbutamol sulphate by (water in oil) in oil emulsion technique using ethyl cellulose as the retardant material. various processing and formulation parameters such as drug/polymer ratio, stirring speed, volume of processing medium were optimized to maximize the e...

The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4...

this study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. the immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...