Objective(s): Inflammation is an immune response toward injuries. Although inflammation is healing response, but in some condition it will lead to chronic disease such as rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, Alzheimer’s and various cancer. Indonesian cassia (Cinnamomum burmanni C. Nees & T. Ness) known to contain coumarin, is widely used for alternative medicine es...

febrile collected from members of both groups and serum samples were prepared. interleukin 1β concentrations were measured using a commercial enzyme-linked immunosorbent assay (elisa) kit. we found that there was a difference in serum levels of interleukin 1β between fc and control  group but  it was not  significant. this result may be due to  the low number  of samples  or  the  result  of  i...

Background As COVID-19 immunomodulation has been a part of interest for studies, it found that severe coronavirus disease 2019 (COVID-19) is associated with hyper-inflammatory response and increased levels interleukin-6 (IL-6) interleukin-10 (IL-10). This can progress to cytokine storm syndrome eventually development acute respiratory distress (ARDS). Interleukin-1 receptor antagonist (IL-1RA) ...

Background: About 5–10% of patients with asthma suffer from poorly-controlled disease despite corticosteroid (CS) therapy. Methods: 21 severe and 30 mild asthma patients were recruited and underwent collection of blood sample. We determined whether there were any differences in inflammatory biomarkers between severe and mild asthma patients or not.Results: Levels of Interleukin-8 (IL-8) and Int...

Background: Interleukin-1 receptor antagonist (IL-1Ra) also known as Anakinra is a of IL-1 especially IL-1β. IL-1β increased in infected COVID-19 patient groups. This study aimed that the IL-1Ra contained Conditioned Medium Wharton’s Jelly Mesenchymal Stem Cells (CM-WJMSCs) has potential to inhibit which one cytokine storms occur COVID patients through an in-silico approach. Objective: aims det...

Introduction: The clinical outcome of patients with squamous cell carcinoma (SCC) located in the head and neck has remained poor despite ongoing advances in diagnosis and management. Interleukin-6(IL-6) is a multi-functional cytokine that plays an important role in the process of cell differentiation and is increased in several malignancies. The aim of this study was to investigate the serum le...

Interleukin 1 (IL-1) and interleukin 6 (IL-6) are typical examples of multifunctional pro-inflammatory cytokines involved in the regulation immune response, hematopoiesis, inflammation. Both peripheral intraventricular administration these causes acute phase symptoms, e.g. fever, activation hypothalamic-pituitary-adrenal axis psychological depression. The amygdala belongs to structures limbic s...

Cytokines are important regulators of the immune system, and identifying fish cytokines has potential applications for the development of vaccines and/or immunostimulants application in fisheries. In order to understand the immune-related genes triggered by immunostimulants derived from pathogens, we investigated the effects of agonists (lipopolysaccharide (LPS), Poly I:C, and imiquimod) of thr...

Objective(s): To reveal the detailed mechanism underlying the functions of salidroside on the inflammation of intestinal epithelial cells during IBD.Materials and Methods: Quantitative real-time PCR was employed to assess the expression of IL-6, IL-10, and α-defensins 5 and 6. ELISA assay was performed to measure the secretion of IL-6 and IL-10. MTT assay was used to determine the cell viabilit...

about 25-50% of graves' disease (gd) patients develop thyroid eye diseases, which is associated with inflammatory process and abnormalities in the levels of several cytokines in orbital tissues in gd.  the aim of this study was to determine the th1 and th2 serum cytokines in patients with gd with or without ophthalmopathy. serum  levels of  cytokines  and  autoantibodies  including interferon-g...