background in some autoimmune diseases such as rheumatoid arthritis (ra), interleukin-27 (il-27) and il-33 levels are increased. these observations suggest that il-27 and il-33 may have a role in the pathogenesis of polymyositis/dermatomyositis (pm/dm). conclusions these data indicate that il-27 might be selectively involved in the pathogenesis of dm and pm. however, il-33 does not appear to be...

Complex interactions between effector T cells and Foxp3(+) regulatory T cells (Treg) contribute to clinical outcomes in cancer, and autoimmune and infectious diseases. Previous work showed that IL-12 reversed Treg-mediated suppression of CD4(+)Foxp3(-) T cell (Tconv) proliferation. We and others have also shown that Tregs express T-bet and IFN-γ at sites of Th1 inflammation and that IL-12 induc...