نتایج جستجو برای: intellectual developmental disorder

تعداد نتایج: 734056  

2017
Martina Barnevik Olsson Anette Holm Joakim Westerlund Åsa Lundholm Hedvall Christopher Gillberg Elisabeth Fernell

BACKGROUND Studies on autism have tended to focus either on those with intellectual disability (ie, those with intellectual quotient [IQ] under 70) or on the group that is referred to as "high-functioning", that is, those with borderline, average or above average IQ. The literature on cognition and daily functioning in autism spectrum disorder combined specifically with borderline intellectual ...

Not so long ago, people with intellectual and developmental disabilities were deprived of their primary rights and many people fought against this discrimination to achieve these rights and sought equal rights as everyone in the society through self-advocacy movement. The main purpose of this movement is empowering and enhancing people with intellectual and developmental disabilities’ con...

Journal: :Cell 2012
James P. Clement Massimiliano Aceti Thomas K. Creson Emin D. Ozkan Yulin Shi Nicholas J. Reish Antoine G. Almonte Brooke H. Miller Brian J. Wiltgen Courtney A. Miller Xiangmin Xu Gavin Rumbaugh

Mutations that cause intellectual disability (ID) and autism spectrum disorder (ASD) are commonly found in genes that encode for synaptic proteins. However, it remains unclear how mutations that disrupt synapse function impact intellectual ability. In the SYNGAP1 mouse model of ID/ASD, we found that dendritic spine synapses develop prematurely during the early postnatal period. Premature spine ...

Journal: : 2021

Objective: Malformations of cortical development (MCD) are rare central nervous system abnormalities that caused by disruption normal stages, including neural cell proliferation, type differentiation, neuronal migration, and final positioning. It has different phenotypic presentations which largely depend on the underlying cause disorder is associated with other neurologic systemic disorders. M...

2014
Yuka Yasuda Ryota Hashimoto Ryoko Fukai Nobuhiko Okamoto Yoko Hiraki Hidenaga Yamamori Michiko Fujimoto Kazutaka Ohi Masako Taniike Ikuko Mohri Mitsuko Nakashima Yoshinori Tsurusaki Hirotomo Saitsu Naomichi Matsumoto Noriko Miyake Masatoshi Takeda

Autism spectrum disorder is a neurodevelopmental disorder characterized by impairments in social interactions, reduced verbal communication abilities, stereotyped repetitive behaviors, and restricted interests. It is a complex condition caused by genetic and environmental factors; the high heritability of this disorder supports the presence of a significant genetic contribution. Many studies ha...

Journal: :Current opinion in psychiatry 2014
Stephen Greenspan George W Woods

PURPOSE OF REVIEW Adoption of the term intellectual disability (intellectual developmental disorder, IDD) in DSM-5 represents a shift from a disability (test score) emphasis to a disorder (medical/neurobiological) emphasis. Several implications of this shift for definition and diagnosis of intellectual disability (ID) are discussed. RECENT FINDINGS The intellectual disability (IDD) section of...

Journal: :European Psychiatry 2023

Introduction Intellectual Developmental Disorder (IDD) is diagnosed with cognitive and adaptive behaviour evaluations. There increasing evidence of a high prevalence psychiatric disorders comorbid IDD. The relationship between specific dysfunctions vulnerability may provide the basis for paradigm shift from “intellectually below average IQ” to “neuropsychological characterization”. Objectives 1...

2017
Martina Busè Helenia C Cuttaia Daniela Palazzo Marcella V Mazara Salvatrice A Lauricella Michela Malacarne Mauro Pierluigi Simona Cavani Maria Piccione

BACKGROUND Recurrent reciprocal 1q21.1 deletions and duplications have been associated with variable phenotypes. Phenotypic features described in association with 1q21.1 microdeletions include developmental delay, craniofacial dysmorphism and congenital anomalies. The 1q21.1 reciprocal duplication has been associated with macrocephaly or relative macrocephaly, frontal bossing, hypertelorism, de...

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