Iniencephaly is a rare form of neural tube defect (NTD) that has been documented in human beings and rats,” but not in the European (domestic) ferret (Mustela putoriusfuro). The term iniencephaly, derived from the Greek word “inion,” meaning “the nape of the neck,” is applied to a syndrome characterized by the following features: 1) deficiency of the occiput, 2) rachischisis (congenital fissure...

6 McLain D, Harper SM, Roe DA, Babish, JG, Wilkinson CF: Congenital malformations and variations in reproductive performance in the ferret: effects of maternal age, color and parity. Lab Anim Sci 35251-255, 1985 7 Milunksy A, Jick H, Hick SS et al.: Multivitamin/folic acid supplementation. J Am Med Assoc 262:2847-2852, 1989 8 Mulinare J, Corder0 JF, Erickson JD, Berry RJ: Periconceptional use o...

This 23-year-old primigravida had history of having taken Clomiphene for 2 consecutive cycles starting on day 5 of her menstrual cycle (50 mg for five days). After the 2nd cycle of clomiphene, she became pregnant. There was no history of taking any other drug for infertility or folate tablets periconceptionally. An ultrasound at 20 weeks showed neural tube defect. At 22 weeks of gestation, she ...