runx3, a member of runt-related transcription factor (runx) proteins with tumor suppressor effect, is a tissue–restricted and cancer related transcription factor that regulate cell proliferation and growth, as well as differentiation. in the present study, exogenous run3 was transiently expressed in ags (human gastric adenocarcinoma), with undetectable runx3 protein and in a549 (human lung carc...

The aim of this study was to analyze the effect heme synthesis inhibition on cytoglobin expression and its correlation with keloid fibroblast viability proliferation. conducted primary culture fibroblasts. Heme in fibroblasts inhibited using succinyl acetone. We measured ALAD enzyme activity a colorimetric method; mRNA qRT-PCR; protein ELISA immunocytochemistry; MTT test; proliferation BrdU tes...

Background/Aim: Androgen receptor (AR) degradation is the primary regulator of androgen activity. This study was designed to investigate influence proteasome on AR protein stability after enzalutamide (Enz) treatment. Materials and Methods: Cell counting treatment utilized assess effect Enz cell proliferation. Changes in mRNA levels were evaluated using reverse transcription-polymerase chain re...

In vitiligo, autoreactive CD8+T cell is established as the main culprit considering their pathogenic role in mediating epidermal melanocyte-specific destruction. Macrophage migration inhibitory factor (MIF) a pleiotropic molecular that plays central various immune processes including activation and proliferation of T cells. But whether MIF intertwined vitiligo development progression its implic...