ABSTRACT New antifungals are needed, particularly in the developing world, to treat life-threatening fungal infections, such as cryptococcosis. Drug repurposing is one strategy to identify new drug-like compounds, but it is often difficult to identify a mechanism of action. Here we discuss the outstanding effort by Butts et al. to identify calmodulin as an antifungal target of repurposed estrog...

brain injury is a complex event leading to tissue damage and functional deficits by primary and secondary mechanisms. since the application of tissue engineering approaches is a new topic in the treatment of brain injury, producing a proper experimental model to evaluate the effects of tissue engineering products on damaged brain tissue is required. in the present study, a simple and reproducib...

spinal cord injury (sci) leads to a significant health problem associated with a broad range of secondary complications and disabilities. in this regard, animal models can help us to understand the pathobiology of sci and evaluate the effects of potential treatments for sci. in contusion models of sci, different devices including surgical spring-loaded clips, balloons, forceps, weights and the ...