Although tuberculin test is widely used for detection of tuberculous infection among children, there is no clear understanding about its performance and interpretation. This article has been written with the purpose of elucidating the performance and interpretation of standard tuberculin test, based on the experiences gained at the National Tuberculosis Institute, Bangalore and other centres. T...

A 55-year-old physician had a PPD made as part of a clinical evaluation. Laboratory tests were unremarkable and PPD, read in 48 hours, showed an area of induration of 18 mm and an erythema of 51 mm (Panel A). A 2 mm punch biopsy was done in the center of the induration 96 hours after the injection. Histopathology showed an intense perivascular cuffing with macrophages and lymphocytes and edema ...

Background: The tuberculin skin test (TST) is the most common method for detecting latent tuberculosis infection (LTBI). The test requires that a patient return to the health facility or be visited by a health care worker 48 to 72 hours after the intradermal placement of tuberculin so that the size of the resulting skin induration, if any, can be measured. Objective: This study aimed to propose...

infection by m. tuberculosis can be demonstrated by tuberculin testing. on sequential ppd some person show a marked increase in the size of their skin reactions which may not be due to recent or past tuberculous infection. this phenomenon (booster effect) can occur as soon as a week after the initial test and persist for as long as a year. methods and materials: the purpose of this research is ...

BACKGROUND Patients with end-stage renal disease (ESRD) and Mycobacterium tuberculosis infection pose a high risk of developing active TB disease. It is therefore important to detect latent TB infection (LTBI) to be able to offer treatment and prevent progression to TB disease. We assessed the value of the tuberculin skin test (TST) and of an interferon-gamma release assay (Quantiferon®-TB Gold...

Ganley, J. P. (Office of Biometry and Epidemiology, National Eye Institute, NIH, Bethesda, Md. 20014), R. E. Smith, D. B. Thomas, G. W. Comstock and P. E. Sartwell. Booster effect of histoplasmin skin testing in an elderly population. Am J Epidemiol 95: 104-110, 1972.—A second histoplasmin skin test was administered to 97 individuals aged 50 years or older who had less than 7 mm of induration o...

Tuberculin sensitivity or post vaccinial allergy (PVA) is widely used as an indicator of successful BCG vaccination. The protection conferred by BCG vaccination, the duration of post-vaccinial allergy and the relationship between the two remain a subject of controversy. The present study was conducted with the aim of finding the duration of PVA and evaluate the need for revaccination. One thous...