Correspondence to: Lai-Wa Kwok Abstract: Glucocorticoid-induced osteoporosis is the most common cause of drug-induced osteoporosis, leading to fragility fractures, decrease in mobility and quality of life. Patients who receive equivalent dose of prednisolone 5 mg for more than six months are at risk of glucocorticoid-induced osteoporosis, but there is no conclusive evidence for a safe cutoff fo...

Background: Osteoporosis one of the postmenopausal symptoms is characterized by bone loss. There is a link between excessive reactive oxygen species (ROS) formation, estrogen deficiency due to cessation of ovarian function and bone loss. Free radicals are responsible for causing osteoblast apoptosis and reducing osteoblastogenesis in bone remodeling. Vitamin E is a potent antioxidant with the a...

Glucocorticoid-induced osteoporosis is one of the most important side-effects of glucocorticoid use, leading to an increased fracture risk. In this review, recent advances in the understanding of the mechanisms of glucocorticoid-induced osteoporosis are summarised. Methods to identify persons at risk for fractures are discussed, as well as the new ACR recommendations for the prevention and trea...

Allosteric Activation of Transglutaminase 2 (TGM2) serves as a cellular target small molecule forskolin to promote osteoblast differentiation and ameliorate ovariectomy-induced osteoporosis. Forskolin binds TGM2 on previously undisclosed allosteric site activate by inducing an “open” conformation, thereby improving mitochondrial energy metabolism for osteoporosis treatment. More details can be ...

Glucocorticoid therapy is the most common cause of secondary osteoporosis and the leading iatrogenic cause of the disease. Often, the presenting manifestation is fracture, which occurs in 30% to 50% of patients receiving long-term glucocorticoid therapy. Glucocorticoid-induced osteoporosis predominantly affects regions of the skeleton that have abundant cancellous bone such as lumbar spine and ...

BACKGROUND AND PURPOSE Refracture after percutaneous vertebroplasty in patients receiving oral glucocorticoid therapy has caused some patients and referring physicians to have negative perceptions concerning the efficacy of the initial vertebroplasty treatment. The purpose of this study was to analyze symptomatic refractures after vertebroplasty in patients on oral steroid therapy. We hypothesi...

INTRODUCTION Corticosteroids have major effects on calcium metabolism, leading to accelerated osteoporosis and fracture. METHODS This review will attempt to summarise current knowledge about their effects in light of new information and important remaining questions, especially with respect to management of this common condition. RESULTS Corticosteroids affect bone through multiple pathways...

Corticosteroid-induced osteoporosis is the most common form of secondary osteoporosis and the first cause in young people. Bone loss and increased rate of fractures occur early after the initiation of corticosteroid therapy, and are then related to dosage and treatment duration. The increase in fracture risk is not fully assessed by bone mineral density measurements, as it is also related to al...

Glucocorticoid drugs interact with bone metabolism at many levels, but their principal action is to reduce osteoblast number and bone matrix synthesis. Virtually all patients receiving glucocorticoids in doses above 5 mg per day lose bone, the amount lost being dependent on the cumulative steroid dose. The risk of fracture is also related to the individual's initial bone density, which in turn ...