BackgroundThe clinical outcome of hypertrophic cardiomyopathy patients is not only determined by the disease-causing mutation but influenced a variety disease modifiers. Here, we defined role location and mutant protein dose troponin T mutations I79N, R94C R278C.Methods resultsWe myofilament function after exchange in permeabilized single human cardiomyocytes as well cardiac patient samples har...

Chrysanthemum is one of the ornamental plants that cultivated widely in worldwide. This flower is one of the most important cut and pot flowers in the world due to its high diversity of colors and shapes. The creation of mutation is an important method for the production of new cultivars, and many cultivars have been produced through spontaneous and induced mutations. In this study, explants of...

Patients carrying the heterozygous A414G mutation in HCN4 gene, which encodes protein, demonstrate moderate to severe bradycardia of heart. Tetramers subunits compose ion channels sinus node that carry hyperpolarization-activated ‘funny’ current (If), also named ‘pacemaker current’. If plays an essential modulating role pacemaker activity. To assess mechanism by results bradycardia, we first pe...

zebra fish were exposed to environmentally relevant concentration of pesticides and metals fora period of 14 days. the individual and the combined toxicity of pesticides and metals were studied. damage caused to the dna and induction of mutation in the gadd45β gene was investigated in this study. the present investigation revealed that exposure of zebra fish to pesticides and metals induced dna...

We study exact Lagrangian fillings of Legendrian links $D_n$-type in the standard contact 3-sphere. The main result is existence a filling, represented by weave, such that any algebraic quiver mutation associated intersection can be realized as geometric weave mutation. method proof via calculus and construction appropriate 1-cycles whose intersections realize required numbers. In particular, w...