introduction: indomethacin increases generation of mitochondrial reactive oxygen species (ros) which have a crucial role in the indomethacin-induced gastric ulcer. coenzyme q10 has an antioxidant activity on mitochondria and cell membranes and protects lipids from oxidation and is essential for stabilizing biological membranes. superoxide dismutase (sod) acts as one of the defense mechanisms ag...

The objective of present study is to investigate anti-ulcer activity of Artocarpus heterophyllus Lam. leaves extracts on indomethacin induced ulcers in rats and establish the probable mechanism of antiulcer activity, if any and confirm the validity of claims of the activity as mentioned in texts as traditional medicines. The leaves were extracted with methanol and anti-ulcer activity was evalua...

This research investigated the effect of Andrographis paniculata (AP) on oxidative stress following indomethacin-induced gastric ulcer in rats. A total 20 male albino Wistar rats (150-180g) used for this study were grouped into four (n=5): 1, Negative Control; 2, Positive Control and 3, test group treated with normal chow, 20mg/kg indomethacin, mg/kg indomethacin plus omeprazole at AP 16.7 resp...

The aim of the study was to study the anti-ulcer activity of the methanolic extract of the leaves of Capparis zeylanica Linn on experimental animal models. The methanol extract of Capparis zeylanica Linn. leaves was investigated for anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats. HCl-Ethanol induced ulcer in mice and indomethacin induced ulcer in rats at...

Helicobacter pylori infection, excessive consumption of alcohol and the prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDS) are the major factors that cause peptic ulcer. Previous studies from our lab revealed the potency of the ethanol extract of the plant, Cardiospermum halicacabum Linn. against ethanol induced gastric ulcerogenesis in rats. The present study intended to compare th...

  Background: Saffron is the dried stigmata of the flowers of saffron (Crocus sativus L., Iridaceae). Saffron is well known for the treatment of gastric disorders in traditional medicine.   Objectives: In the search for new potential antiulcer agents, the effects of the ethanol extract of saffron and its active constituents crocin and safranal as compared with omeprazole against gastric ulcer i...

The herbal medicines derived from various plants extracts are being increasingly utilized to treat a wide variety of clinical diseases 1 . Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers 2 . The study was designed to investigate the anti-ulcer effect of chloroform extract of Chrozophora plicata leaves (600mg/kg) against experimentally induced ulcer mo...

OBJECTIVE To determine the potential antiulcer activity of methanol extract of Melastoma malabathricum leaves (MEMM) using various established rat models. MATERIALS AND METHODS Ten groups of rats were used and orally administered 10% DMSO (negative control), 100 mg/kg ranitidine (positive control) or MEMM (50, 250 and 500 mg/kg) followed by gastric ulcer induction either using ethanol or indo...

background: saffron is the dried stigmata of the flowers of saffron (crocus sativus l., iridaceae). saffron is well known for the treatment of gastric disorders in traditional medicine.   objectives: in the search for new potential antiulcer agents, the effects of the ethanol extract of saffron and its active constituents crocin and safranal as compared with omeprazole against gastric ulcer ind...

Anti gastric ulcer activity of root, stem and leaves of Amaranthus spinosus Linn. was studied against ethanol, hydrochloric acid, indomethacin, stress and pyloric ligation induced gastric ulceration in albino rats. Omeprazole was used as standard anti gastric ulcer drug. Significant anti gastric ulcer activity was noted in root, stem and leaves of Amaranthus spinosus Linn. Root of the plant, ho...