نتایج جستجو برای: indolent

تعداد نتایج: 5476  

2016
Stefan Ehrentraut Björn Schneider Stefan Nagel Claudia Pommerenke Hilmar Quentmeier Robert Geffers Maren Feist Maren Kaufmann Corinna Meyer Marshall E. Kadin Hans G. Drexler Roderick A. F. MacLeod

We propose that deregulated T-helper-cell (Th) signaling underlies evolving Th17 cytokine expression seen during progression of cutaneous T-cell lymphoma (CTCL). Accordingly, we developed a lymphoma progression model comprising cell lines established at indolent (MAC-1) and aggressive (MAC-2A) CTCL stages. We discovered activating JAK3 (V722I) mutations present at indolent disease, reinforced i...

Journal: :The Lancet. Oncology 2014
Laura J Esserman Ian M Thompson Brian Reid Peter Nelson David F Ransohoff H Gilbert Welch Shelley Hwang Donald A Berry Kenneth W Kinzler William C Black Mina Bissell Howard Parnes Sudhir Srivastava

A vast range of disorders--from indolent to fast-growing lesions--are labelled as cancer. Therefore, we believe that several changes should be made to the approach to cancer screening and care, such as use of new terminology for indolent and precancerous disorders. We propose the term indolent lesion of epithelial origin, or IDLE, for those lesions (currently labelled as cancers) and their prec...

Journal: :Haematologica 2011
Michelle Furtado Simon Rule

Effect of graft source on unrelated donor haemopoietic stem-cell trans-plantation in adults with acute leukaemia: a retrospective analysis. al. Unrelated transplantation for poor-prognosis adult acute lym-phoblastic leukemia: long-term outcome analysis and study of the impact of hematopoietic graft source. R, et al. Favorable outcome of unrelated cord blood transplantation for Philadelphia chro...

Journal: :Annals of the rheumatic diseases 1983
D G Macfarlane J T Bourne P A Dieppe D L Easty

Classical Wegener's granulomatosis is a relentlessly progressive and rapidly fatal disease. A pulmonary 'limited form' is associated with a much better prognosis. We report 3 cases of Wegener's granulomatosis which ran a prolonged indolent course despite major manifestations outside the lower respiratory tract and review the literature on survival.

Journal: :Seminars in hematology 2010
Tarek Sousou Jonathan Friedberg

Indolent non-Hodgkin lymphoma (NHL) comprises a group of incurable, generally slow-growing lymphomas highly responsive to initial therapy, with a relapsing and progressive course. Rituximab, an anti-CD20 antibody, has had a large impact on the treatment of indolent NHL. Its effectiveness as a single agent and in conjunction with known chemotherapy regimens has made it a standard of care in the ...

2014
Peter E. Blase Pieternel C. M. Pasker-de Jong Anton Hagenbeek Rob Fijnheer Marie J. de Haas John M. H. de Klerk

Backgrounds and Purpose—In indolent non-Hodgkin lymphoma, histological transformation is a dramatic event which reduces the prognosis significantly. SUVmax values from FDG-PET/CT help differentiate between aggressive and indolent lymphomas, and transformed indolent lymphomas also show an increased FDG uptake. Possibly FDG uptake increases early in the clinical course and could predict histologi...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2004
S A Pileri P L Zinzani P Went A Pileri M Bendandi

Indolent lymphomas have recently been the object of numerous studies, which have focused on new aspects relevant both for the better comprehension of their histogenesis and the identification of new therapeutic strategies. As marginal-zone lymphoma (MZL) represents the category of indolent lymphomas that has obtained more benefit from such an approach, the authors focused on the most recent ach...

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