نتایج جستجو برای: indoleamine 2

تعداد نتایج: 2526824  

2017
Felicita F Jusof Supun M Bakmiwewa Silvia Weiser Lay Khoon Too Richard Metz George C Prendergast Stuart T Fraser Nicholas H Hunt Helen J Ball

Indoleamine 2,3-dioxygenase-2 (IDO2) is 1 of the 3 enzymes that can catalyze the first step in the kynurenine pathway of tryptophan metabolism. Of the 2 other enzymes, tryptophan 2,3-dioxygenase is highly expressed in the liver and has a role in tryptophan homeostasis, whereas indoleamine 2,3-dioxygenase-1 (IDO1) expression is induced by inflammatory stimuli. Indoleamine 2,3-dioxygenase-2 is re...

2012
Svetlana E Nikoulina Dietmar Fuchs Phillip Moheno

Calcium pterins have been shown to be significant immunotherapeutic agents in models of breast cancer, hepatitis B, and tuberculosis (Bacillus Calmette-Guérin mycobacteria). These compunds modulate the immuno-enzyme indoleamine 2,3-dioxygenase (IDO) and the blood levels of several identified inflammatory cytokines. Recent research into the pathology of diabetes implicates inflammatory factors i...

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