OBJECTIVE To estimate the cost-effectiveness of growth hormone (GH) therapy for idiopathic short stature (ISS). DESIGN Cost-effectiveness analysis. SETTING Decision model. PATIENTS A cohort of 10-year-old prepubertal boys with ISS treated with GH. INTERVENTIONS Comparison of children treated for 5 years with GH therapy vs children receiving no intervention. MAIN OUTCOME MEASURES Incre...

The aim of incremental analysis is, given a program, its analysis results, and a series of changes to the program, to obtain the new analysis results as efficiently as possible and, ideally, without having to (re-)analyze fragments of code which are not affected by the changes. Incremental analysis can significantly reduce both the time and the memory requirements of analysis. The first contrib...

BACKGROUND The NCIC Clinical Trials Group conducted the BR.21 trial, a randomized placebo-controlled trial of erlotinib (an epidermal growth factor receptor tyrosine kinase inhibitor) in patients with previously treated advanced non-small cell lung cancer. This trial accrued patients between August 14, 2001, and January 31, 2003, and found that overall survival and quality of life were improved...

California and Maryland hospital data are used to estimate the incremental cost associated with 64 categories of hospital acquired complications. The reason for admission, severity of illness at admission and the presence of hospital acquired complications are used in a linear regression model to predict incremental per patient cost yielding an adjusted R2 of 0.58 for Maryland data and 0.60 for...

Sunk cost effect (also called escalation of commitment, etc) is a pervasive, interesting and famous decision bias, which has been intensively discussed in psychology, economics, management, political science, zoology, etc. To date, little has been known about the neural basis of this phenomenon. We investigated it by using functional magnetic resonance imaging (fMRI) to monitor healthy subjects...

Incremental heuristic searches try to reuse their previous search efforts whenever these are available. As a result, they can often solve a sequence of similar planning problems much faster than planning from scratch. State-of-the-art incremental heuristic searches such as LPA*, D* and D* Lite all work by propagating cost changes to all the states on the search tree whose gvalues (the costs of ...