Chloroform and other trihalomethanes are contaminants of drinking water that have been demonstrated to be carcinogenic in laboratory animals. Determination of the mechanism of carcinogenicity of chloroform is required so that the animal data can be extrapolated to estimate the human health hazard. The extent of the binding of chloroform to rat liver and kidney DNA was approximately 0.1% the lev...

Herein, we discuss the synthesis, structural and spectroscopic characterization, biological activity of five heteroligand copper(II) complexes with diethylnicotinamide various fenamates, as follows: flufenamate (fluf), niflumate (nifl), tolfenamate (tolf), clonixinate (clon), mefenamate (mef) N, N-diethylnicotinamide (dena). The composition: [Cu(fluf)2(dena)2(H2O)2] (1), [Cu(nifl)2(dena)2] (2),...

In the crystal structure of the title Co(II) complex, [Co(C(8)H(5)O(3))(2)(C(10)H(14)N(2)O)(2)(H(2)O)(2)], the metal centre is located on an inversion center and is coordinated by two 4-formyl-benzoate (FOB), two diethyl-nicotinamide (DENA) ligands and two water mol-ecules in a slightly distorted CoO(4)N(2) octa-hedral geometry. In the crystal structure, O-H⋯O hydrogen bonds link the mol-ecules...

The chlorinated hydrocarbons chloroform (CHCl3), 1,1-dichlorethane (1,1-DCE) and 1,2-dichloroethane (1,2-DCE) have been detected in finished drinking water. When administered to B6C3F1 mice by gavage in corn oil, these compounds have been shown to induce hepatic tumors. The present study examines the effect on liver tumor incidence of continuous treatment of CHCl3 (600 mg/L and 1800 mg/L), 1,1-...

By using cDNA microarrays, we studied the expression profiles of 26 hepatocellular carcinomas (HCC) developing spontaneously in peroxisomal fatty acyl-CoA oxidase null (AOX-/-) mice. The development of liver tumors in AOX-/- mice is due to sustained activation of peroxisome proliferator-activated receptor alpha (PPARalpha) by the unmetabolized substrates of AOX, which serve as natural PPARalpha...

The NNW-trending Dena Fault, with 140 km length, cuts the major structures of Zagros Fold-Thrust Belt in Borujen region. The fault has divided the region in two zones, in which different structural, andmorphological features as well assedimentation and seismtectonic characteristics have developed. This study presents a new interpretation for the kinematics of Dena Fault based on field evidence....

background & aim: verbascum songaricum is a perennial herbaceous belongs to the scrophulariaceae (snapdragon) family. current study was done to study the environmental conditions effect on phytochemical properties of verbascum songaricum leaves for extracting the effective materials. experimental: this study was conducted at five range sites, including hoze valley, ghahiz, someirom, ghale ...

investigating species diversity and richness is essential for defining conservation priorities. in addition, determining landscape parameters influencing species diversity and richness is important for selecting and designing parks and protected areas. kohgiluyeh & boyer ahmad province is a mountainous region, comprises hills, mounds, forests and plains. this vast province has high species dive...