RANKL: Receptor activator of nuclear factorkappa B ligand; PTHrP: Parathyroid Hormone Related Peptide; ACTH: Adrenocorticotropic Hormone; POMC: Pro-Opiomelanocortin; PNES: Paraneoplastic Endocrine Syndrome; OPG: Osteoprotegrin; CS: Cushing’s Syndrome; CLIP: Corticotrophin-Like Intermediate Lobe Peptide; MSH: α-Melanocyte Stimulating Hormone; CLIP: Corticotrophin-Like Intermediate Lobe Peptide; ...

The population of elderly persons is growing with extraordinary rapidity. Although the majority enjoys good health, many older people suffer from multiple illnesses and significant disability. They tend to exhibit great medical complexity and vulnerability; have illnesses with atypical and obscure presentations; suffer major cognitive, affective, and functional problems; are especially vulnerab...

BACKGROUND The number of out-of-hours calls to general practitioners (GPs) has increased steadily during the past 20 years. The proportion of inappropriate calls are reportedly increasing but we know very little about how GPs judge a call to be appropriate or inappropriate. AIM To determine the factors that influence GPs' perceptions of the appropriateness or inappropriateness of out-of-hours...

The aim of this study was to determine the role played by vigilance on the anaerobic performance recorded during a Wingate test performed at the bathyphase (nadir) of the circadian rhythmicity. Twenty active male participants performed a 60-s Wingate test at 6 a.m. during 3 test sessions in counter-balanced order the day after either (i) a normal reference night, (ii) a total sleep deprivation ...

Two young women are described who presented with an acute psychiatric illness, due to the metabolic effects of inappropriate anti-diuretic hormone (ADH) secretion. In both patients symptoms were promptly abolished by correction of the biochemical disturbance and subsequent investigations revealed hitherto occult oat cell carcinoma of bronchus. These patients demonstrate the value of routine lab...

Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) refers to the excessive release of antidiuretic hormone (ADH) resulting in water retention, dilutional hyponatremia and urinary sodium waste, and some other clinical manifestations. Causes of SIADH include many disease conditions, some medications and nicotine. The present study reports a case of psychosis followed by lung canc...

Over the last few years, there has been a rapid and steadily expanding demographic explosion in the elderly population in France. When the most dynamic segment of this growth is considered, i.e. patients aged 80 years or more (who, moreover, usually have several diseases), under- or over-prescribing and/or inappropriate prescribing are identified. Three short- and medium-term recommendations ar...