In the 'omic' era, hundreds of genomes are available for protein sequence analysis, and some 30 per cent of all sequences are of membrane proteins. Unlike globular proteins, a 3D model for membrane proteins can hardly be computed starting from the sequence. Why is this so? What can we really compute and with what reliability? These and other matters are outlined.

Article history: Received 16 October 2014 Received in revised form 8 May 2015 Accepted 30 June 2015 Available online 3 July 2015

• Topology of G/T : Flag manifolds G/T have cohomology only in even degrees, with Euler characteristic the degree of the Weyl group. The Euler characteristic can be calculated by a Lefschetz fixed point argument (see Adams [1], pgs. 90-92 for this). Identifying the flag manifold with a co-adjoint orbit, there is a Morse theory calulation of the cohomology that goes back to Bott, for an outline ...

conclusions the levels of knowledge and skill among iranian physicians on major topics of sports and exercise medicine are low to medium. gps and interns are the first line of patient management so our findings suggest adding some sports medicine related topics into curriculum of medical doctors. materials and methods a cross-sectional study was performed in 2009 to determine the knowledge rega...