Ocular drug delivery is limited both by patient acceptability and by the limited time that the dosage form is retained within the precorneal region. The timely gelation and retention of in situ-gelling ophthalmic formulations would be fundamental to improve the efficacy of drugs. The aim of this investigation was to develop ocular drug delivery system with simplicity in installation for patient...

An in situ heparin-based forming hydrogel that cures under visible-light is formulated using eosin Y as a photoinitiator with triethanolamine as an electron donor to initiate reaction of thiolated-heparin with acrylate-ended poly(ethylene glycol). Formulations and irradiation conditions are presented for control of heparin content (1.6 to 3.3% w/v), modulus (100-10,000 Pa), and gelation time (3...

The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 3(2) full factorial design was employed with two polymers: Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesio...

The in situ formation of injectable silk fibroin (SF) hydrogels have potential advantages over various other biomaterials due to the minimal invasiveness during application. Biomaterials need to gel rapidly under physiological conditions after injection. In the current paper, a novel way to accelerate SF gelation using an anionic surfactant, sodium dodecyl sulfate (SDS), as a gelling agent is r...

Chitosan can readily dissolve in a precooled aqueous alkali-urea solution, a solvent that has previously been developed to dissolve cellulose. Upon heating, the resulting solutions quickly become a gel. The thermal gelling of the chitosan solutions was studied by rheology. Initially, a temperature ramp test was used to determine the gelation temperatures (Tgel). It was found that Tgel does not ...

Chitosan (CS) has generated considerable interest for its desirable properties and wide applications. Hydrogel has been proven to be a major and vital form in the applications of CS materials. Among various types of CS hydrogels, physical cross-linked CS hydrogels are popular, because they avoided the potential toxicity and sacrifice of intrinsic properties caused by cross-linking or reinforcem...