The effects of prenatal exposure to the antiandrogen flutamide on two sexually dimorphic nuclei of the lumbar spinal cord, the dorsolateral nucleus (DLN) and the spinal nucleus of the bulbocavernosus (SNB), were investigated. Rat dams were given daily injections of 5 mg flutamide or vehicle alone from day 11 through 21 of pregnancy. The spinal cords and perineal morphology of their male and fem...

We investigate two important properties of real data: diversity and log-normality. Log-normality accounts for the fact that data follow the lognormal distribution, whereas diversity measures variations of the attributes in the data. To our knowledge, these two inherent properties have not been paid much attention from the machine learning community, especially from the topic modeling community....

Layer normalization is a recently introduced technique for normalizing the activities of neurons in deep neural networks to improve the training speed and stability. In this paper, we introduce a new layer normalization technique called Dynamic Layer Normalization (DLN) for adaptive neural acoustic modeling in speech recognition. By dynamically generating the scaling and shifting parameters in ...

Ag delivery via the nasal route typically induces tolerance or fails to polarize CD4+ T cell responses unless an adjuvant is provided. To better understand this process, we assessed the effects of two mucosal adjuvants, Escherichia coli LPS and cholera toxin (CT), on Ag passage and T cell activation in the draining lymph nodes (DLN) of BALB/c mice following per nasal administration of the model...

In this paper we present our system for efficient storage, update, and retrieval of web service metadata documents in relational database. Initially we investigate all of the existing approaches for efficient storage and retrieval of XML documents in relational database. As a result we selected a recently proposed structure-centered storage schema named DLN (Dynamic Level Numbering). As there i...

Impaired immune responses in the elderly lead to reduced vaccine efficacy and increased susceptibility to viral infections. Although several groups have documented age-dependent defects in adaptive immune priming, the deficits that occur prior to antigen encounter remain largely unexplored. Herein, we identify novel mechanisms for compromised adaptive immunity that occurs with aging in the cont...

Background The purpose of this study was to clarify whether pretreatment tumor burden-related index, including the gross tumor volume (GTV) of metastatic lymph nodes (VLN) and maximum diameter of metastatic lymph nodes (DLN), and inflammatory markers, consisting of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), are useful for assessing the therapeutic effects and p...

As a range of daily phenomena, Fake News is quickly becoming longstanding issue affecting individuals, public and private sectors. This major challenge the connected modern world can cause many severe real damages such as manipulating opinion, damaging reputations, contributing to loss in stock market value representing risks global health. With fast spreading online misinformation, checking ma...

Foxp3+ regulatory T cells (Tregs) migrating from the skin to the draining lymph node (dLN) have a strong immunosuppressive effect on the cutaneous immune response. However, the subpopulations responsible for their inhibitory function remain unclear. We investigated single-cell gene expression heterogeneity in Tregs from the dLN of inflamed skin in a contact hypersensitivity model. The immunosup...

Soil fungal communities involved in the biodegradation of polyester polyurethane (PU) were investigated. PU coupons were buried in two sandy loam soils with different levels of organic carbon: one was acidic (pH 5.5), and the other was more neutral (pH 6.7). After 5 months of burial, the fungal communities on the surface of the PU were compared with the native soil communities using culture-bas...