Introduction: Kainic Acid (KA) is an ionotropic glutamate receptor agonist. KA can induce neuronal overactivity and excitotoxicity. Rosmarinic Acid (RA) is a natural polyphenolic compound with antioxidant, anti-apoptotic, anti-neurodegenerative, and anti-inflammatory properties. This study aimed to assess the effect of RA on apoptosis, nNOS-positive neurons number, as well as Mitogen-Activated ...

INTRODUCTION Systemic sclerosis (SSc) complicated by pulmonary arterial hypertension (PAH) carries a poor prognosis, despite pulmonary vascular dilating therapy. Platelet-derived growth factor receptor-β (PDGFR-β) and epidermal growth factor receptor (EGFR) are potential therapeutic targets for PAH because of their proliferative effects on vessel remodelling. To explore their role in SScPAH, we...

conclusions the current study indicated that the immunoreactivity of secretory iga might have no direct correlation with the colonization of indigenous flora and rejection of exogenous strains in adults. the relationship of microbes, host and dental caries should be in the light of coevolved microecosystem as a whole, but not caused by one factor alone. results the results showed that naturally...

Objective: To investigate the possible effect of N-acetylcysteine (NAC) treatment on rat diabetes-induced liver damage and immune reactivity asprosin hormone in liver. Material-Method: Twenty-eight Wistar albino male rats were used study. They separated into 4 groups as Control (n=7), Diabetes Diabetes+NAC NAC (n=7). The all dissected after treatment, tissues taken for pathological examination....

introduction: auger electron based radioimmunotherapy (rit) using 111in-dota-trastuzumab (111in-dota-antiher2) feasibility was studied in vitro on a her2/neu positive cell line, skbr3. methods:111in-dota-antiher2 was prepared according to the optimized conditions followed by quality control tests including radiochemical purity; immunoreactivity). skbr3 as a her2/neu positive cell line was used ...

The goal of this study was to clarify the role p16INK4a, p14ARF, and p53 protein expressions in carcinogenesis squamous cell carcinomas lip. p53, p14ARF proteins were examined 46 formaline-fixed paraffin embedded tissue specimens, which included 19 cases carcinoma lip, 14 actinic cheilitis, 13 normal mucosa. Immunoreactivity peritumoral epithelium adjacent als

Objective(s): The aim of this study was to determine Oxytocin receptor (OTR) gene expression and localization in diabetic and non-diabetic mouse testes by RT-PCR and immunohistochemistry, respectively. Materials and Methods: In this study, 18 male BALB/c mice (8–12 weeks old) were used and divided into three groups: diabetic, sham, and control. Streptozotocin (STZ) was applied to the diabetic g...