Studies of melanocyte and melanoma biology using monocultures of cells are limited because of culture-induced morphology changes and expression of genes related to growth, migration, and invasion, which do not reflect the in situ phenotype of normal melanocytes, nevus cells, or melanoma cells from biologically early progression stages. The development of organotypic cultures of human skin, in w...

This paper contains details of methods and full results of estimates of the incubation period of acquired immunodeficiency syndrome (AIDS) that were outlined in a previous paper by Medley et al. (Nature, Lond. 328, 719 (1987)). The original model is modified to assess the influence of age and sex on the incubation period: age, but not sex, is statistically significant. The difficulties associat...

1. Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran 2. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran 3. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran 4. Department of Immunology...

Societal responses to the very serious problems posed by the scourge of AIDS (acquired immune deficiency syndrome) reflect, at least in part, the epidemiological association that exists between the rampant spread of that deadly disease and homosexual activity. The fact that AIDS has disproportionately affected members of the homosexual community has certainly had an impact upon how the problems...

،مدلا تاهمأب طبترلما )HIV( يرشبلا ةعانلما صقن سوريف دعي .ىودعلل ينلمالحا ينغلابلاو لافطلأا ىدل ًاردان اًيئاعو لًالاتعا قبس تاونس 7 رمعلا نم غلبي لفط ةلاح ةساردلا هذه يف ضرعن ايقلخ ةبستكلما ةيرشبلا ةعانلما صقن سوريف ىودعب هصيخشت ةيلزغم مدلا مأ قزتم نع منج ةيتوبكنعلا تتح فزنل ضرعت يذلاو ةدلم اهصيخشت تم يتلاو يلخادلا يتابسلا نايرشلا يف لكشلا ةحجان ةحارلج لفطلا عضخ .يسيطانغلما يننرلا ريوصتب رهشأ 6 دعت...

During 1994, local, state, and territorial health departments reported to CDC 34,974 cases of acquired immunodeficiency syndrome (AIDS) among men whose only reported HIV exposure was sexual contact with other men. Although previous reports indicated progressively smaller annual increases in cases of AIDS among men who have sex with men (MSM) (1), male-to-male sexual contact continues to represe...

In this issue of Immunity, Pérez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein and show that human immunity to the virus HSV-1 is critically dependent on TRAF3.