diabetes mellitus is a group of metabolic diseases caused by a combination of insulin resistance and impaired insulin secretion by pancreatic β cell. in 2007, 246 million people (roughly 6%) were affected by diabetes worldwide and it is estimated that this will increase to 380 million in 2025. diabetes is associated with several long-term complications such as cardiovascular disease, nephropath...

as igm and iga-enriched preparations are needed to complete the immunotherapeutic spectrum, a simple procedure is described for the preparation of igm and iga enriched immunoglobulins. fraction iii which was prepared by cold ethanol fractionation was treated by octanoic acid followed by ethanol precipitation and ion-exchange chromatography using sephadex deae a-50 and 0.1 m tris-d.35m naci buff...

few biomarkers that can predict the clinical response to allergen immunotherapy (ait) have been identified. the aim of the present study was to investigate parameters that could be used “in predicting the clinical response to ait” in children with asthma caused by house dust mites. we evaluated 107 children with mild persistent asthma who were sensitised only to mite aeroallergens. the study gr...

the clinical behavior of asthma varies with age at onset. this study was undertaken to identify associated markers of adult-onset allergic asthma (age ≥20 years).this cross-sectional study compared two groups: 58 patients with asthma onset at <20 years and 66 with onset at ≥20 years. they were compared depending on results of clinical history, and body mass index (bmi), aeroallergen sensitizati...

hepatitis a virus (hav) infection is a self-limiting disease caused by a 27-nm rna virus from the picorna virus family. its' transmission is primarily via the fecal-oral route. the disease is usually mild and anicteric in children, however the rate of the icteric form, severity, and mortality increase in adult life. the estimated case-fatality rate in age over 40 years is approximately 2%, whil...

introduction: most b-cell malignancies are diagnosed based on morphologic and immunohistochemical criteria. some cases, however, still present a challenge for the pathologist to discriminate between reactive hyperplasia and neoplastic disorders. molecular techniques can be used as a helpful diagnostic tool in these cases. in this study, we assessed the value of polymerase chain reaction (pcr) t...

background: there are varieties of purification techniques for separation of human plasma proteins such as salting out, ion exchange chromatography, and ethanol fractionation. there are limitations for each method, for example in salting out method, the salt has to be removed in an additional step. ion exchange chromatography is difficult for scaling up, and plasma fractionation is a time consu...

Abstract Background Here, we report an atypical HIV-vacuolar myelopathy and search the available medical literature about presentations of human immunodeficiency virus associate vacuolar (HIV-VM) immunoglobulin therapy response. Case A 26-year-old lady who was 4 weeks postpartum presented to us with acute flaccid quadriparesis, no sensory level. Extensive workup ruled out other causes myelopath...

abstract: plasma cellmyeloma constitutes about 10% of all  hematologicmalignancies. metastatic cutaneous lesions without underlying bony involvement are rare and associated with advanced disease, poor prognosis and high tumor burden. igg is the most common subtype and igd is believed to have a more aggressive course.######

tumor necrosis factor- α (tnf-α) plays an important role in diverse cellular events such as septic shock, induction of other cytokines, cell proliferation and apoptosis. tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is currently attracting great interest as a potential anticancer drug. trail could selectively induce apoptosis in tumor cells in vitro and in vivo by a deat...