PURPOSE This study aimed to evaluate the safety and efficacy to induce clinical desensitization to cow's milk (CM) of an oral immunotherapy (OIT) protocol in a pediatric population with cow's milk allergy (CMA). In addition, the immune responses against β-casein, of peripheral blood mononuclear cells (PBMCs) from CMA patients, before and after the protocol were evaluated and compared to a nonal...

background during the recent decades, there have been two major leaps in treatment of depression using the medication to pacify and relieve depression signs and behavior cognitive therapy. the available evidences emphasize the treatment success with some group training methods including stress management, cognitive group therapy, and eye movement desensitization in reducing depression. objectiv...

Immunotherapy of allergic contact dermatitis (ACD) has tantalized allergists since the beginning of the 20th century. The term immunotherapy refers to treatment of disease by either inducing/enhancing or preventing/suppressing an immune response. As contact allergy is an excessive immune reaction to otherwise harmless environmental substances (haptens), immunotherapy of ACD should be aimed at p...

conclusions emdr is an effective tool for curing or decreasing the level of anxiety in myocardial patients. results the findings collected during the 12-month follow-up indicated that emdr was effective for treating anxiety in myocardial patients. materials and methods this study was a clinical trial study. sixty myocardial patients were selected using convenience random sampling and divided in...

Introduction: Amyloid diseases have been known to be hereditary, including transthyretin (TTR) amyloidosis where subunit protein mutations may occur in genes for TTR leading to the deposition of fibrils (low molecular weight subunits (5 to 25 kD) of proteins) in extracellular tissues. By reducing the formation of TTR amyloid, diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), has shown ...

Pathogenic Yersinia spp. uncouple an array of signal transduction pathways in macrophages to disrupt their response to infection. This compels the macrophage to undergo apoptosis. Our study shows that macrophages that had acquired tolerance to Yersinia infection by preexposure to lipopolysaccharide were considerably protected against Y. enterocolitica-induced apoptosis. The desensitization of m...

Usage of cancer chemotherapeutics drugs can be associated with adverse drug reactions. When IgE-mediated drug reactions are formed following administration of a chemotherapeutic drug that is a drug of choice, drug desensitization protocols can be helpful. Hypersensitivity reactions can be allergic or nonallergic, but the clinical manifestations are similar. Rapid drug desensitization (RDD) is e...

Human defensins are natural peptide antibiotics. On the basis of the position and bonding of six conserved cysteine residues, they are divided into two families, designated alpha- and beta-defensins. Human alpha-defensins are expressed predominantly in neutrophils (human neutrophil peptides (HNP) 1-4) or intestinal Paneth cells (human defensins (HD) 5 and 6). Although alpha-defensins have been ...