The immobilisation of proteins on to nanoparticles has a number of applications ranging from biocatalysis through to cellular delivery of biopharmaceuticals. Here we describe a phosphopantetheinyl transferase (Sfp)-catalysed method for immobilising proteins bearing a small 12-mer "ybbR" tag on to nanoparticles functionalised with coenzyme A. The Sfp-catalysed immobilisation of proteins on to na...

A child with systemic onset juvenile chronic arthritis (JCA) who developed a bilateral femuropopliteal vein thrombosis after plaster immobilisation following a tibial fracture is described. When the thrombosis was diagnosed, antiphospholipid antibodies detected either as lupus anticoagulant and anticardiolipin antibodies were found. This suggests that short term prophylatic antithrombotic treat...

The effect of tenotomy and of immobifisation in lengthened and shortened positions on the intramuscular connective tissue of the calf muscles of the rat was studied morphometrically and with a scanning electron microscope. Both tenotomy and immobilisation produced a marked increase in both the endomysial and the periinysial collagen networks, with a simultaneous decrease in intramuscular capill...

In this paper, methods of surface modification of different supports, i.e. glass and polymeric beads for enzyme immobilisation are described. The developed method of enzyme immobilisation is based on Schiff’s base formation between the amino groups on the enzyme surface and the aldehyde groups on the chemically modified surface of the supports. The surface of silicon modified by APTS and GOPS w...

BACKGROUND Acute anterior dislocation, which is the most common type of shoulder dislocation, usually results from an injury. Subsequently, the shoulder is less stable and is more susceptible to re-dislocation, especially in active young adults. This is an update of a Cochrane review first published in 2006. OBJECTIVES To assess the effects (benefits and harms) of conservative interventions a...

The immobilisation of electrocatalysts for CO2 reduction onto light harvesting semiconductors is proposed to be an important step towards developing more efficient CO2 reduction photoelectrodes. Here, we report a low cost nickel cyclam complex covalently anchored to a metal oxide surface. Using transient spectroscopy we validate the role of surface immobilisation on enhancing the rate of photoe...

Radionuclide solubility is one of the factors that can determine the 'source term' for potential migration to the far field. Hence, the mechanisms of immobilisation of radionuclides in cements need close study in order to quantify the nature of the binding. The nature of the binding forces in a cement matrix is very species sensitive, so it is difficult to produce a general description. This re...

The anatomy of the ankle, and the types of sporting injuries that occur in this joint, are described. Traditional treatment of soft tissue injuries involves immobilisation, and the value of this is questioned. An alternative treatment strategy is described, and involves immobilisation and compression for twenty-four hours, followed by rapid mobilisation using a balance board. This alternative s...

In this study three forms of treatment for ruptures of the lateral ligament of the ankle have been compared with reference to their effect upon the final mechanical stability of the ankle, the duration of morbidity immediately after injury, and the incidence of complaints one year after injury. The three forms of treatment used were mobilisation, immobilisation for six weeks, and suture of the ...

BACKGROUND Ankle fractures are common. Management of ankle fractures generally involves a period of immobilisation followed by rehabilitation to reduce pain, stiffness, weakness and swelling. The effects of a rehabilitation program are still unclear. However, it has been shown that important components of rehabilitation programs may not confer additional benefits over exercise alone. The primar...