background : since the introduction of silicone based medical devices in to clinical practice, several reports appeared in the medical literature regarding their adverse effects. however, there are few reports of immunologic reactions to these implants. case presentation : a case of systemic reaction to a breast implant inserted for immediate breast reconstruction in a breast cancer patient is ...

Abstract Background Immediate hypersensitivity reaction to ursodiol is rare and there no previously published protocol on desensitization. Case presentation A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate ursodiol—the first-line treatment for PBC. When she switched a second-line treatment, her PBC continued progress. As such, completed novel 12-step desensitiza...