Alcohol can be considered as a nutritional toxin when ingested in excess amounts and leads to skeletal muscle myopathy. We hypothesized that altered protease activities contribute to this phenomenon, and that differential effects on protease activities may occur when: (1) rats at different stages in their development are administered alcohol in vivo; (2) acute ethanol treatment is superimposed ...

introduction: motor behavior and coordination impairment are known side effects of opioid treatment, yet very few studies have investigated the effects of tramadol on motor behavior, or compared its effect with the effect of an opioid. this study investigates the effects of chronic injection of morphine and tramadol on rat motor function during infancy. methods: neonate rats (n=56) were randoml...

introduction: since discovery of high frequency waves, their biological effects have been in great attention. increased male fertility problems proposed their possible relation to use of microwaves. testes are of very active body tissues, which can be affected by these waves. age of exposure may also be an important factor. methods: this study was carried out to evaluated testosterone level in ...

Cows' milk contains considerable quantities of estrogens, mainly in the form of estrone sulfate (ES). To determine whether the commercial milk has any biologically significant hormonal effects, 2 series of uterotrophic tests were performed, 1 with young ovariectomized rats and the other with sexually immature rats. Thirty-six rats were used for each test. They were divided into 3 groups of 12 a...

introduction: pulsatile injection of gnrh in hypothalamic amenorrhea is known to result in ovulation. the aim of this research was to study the effect of non pulsatile gnrh agonist administration on the ovaries of immature rats. material and methods: in this research the immature rats was divided to 7,17 and 27 daysand each were subdivided to four subgroups. subcutaneous injection every 12 hour...

We investigated a simple method using induced ovulation in immature rats to detect ovarian injury due to chemicals. We investigated the influence of di-(2-ethylhexyl) phthalate (DEHP) on ovulation induced by equine chorionic gonadotropin (eCG) in immature F344 rats. Single injections of 15 and 30 iu eCG induced ovulation in 4 of 6 rats and in all of 4 rats, respectively. The mean number of ovul...

Na-sulfaacetylthiazole, 0.5g/kg body weight, was injected into immature and adult rats to produce obstructive nephropathy. Necrotic changes in the myocardium were found in all of the 9 adult rats of about 120days of age, whereas no such changes occured in immature animals of about 40days of age. Thyrocalcitonin, 50 mMRC units a day injected subcutaneously for one week, completely inhibited the ...

Purpose: One of the most important issues regarding radio frequency electromagnetic fields (RF‐EMF) is their effect on genetic material. Therefore, we investigated the cytogenotoxic effects of 900 MHz radio frequency electromagnetic fields (RF‐EMF) and the effect of a recovery period after exposure to RF‐EMF on bone marrow cells of immature and mature rats. Materials and methods: The immature a...

Effects of ACTH or hCG on the secretion of corticosterone (CB) and progesterone (PRG) from adrenal glands of the female rats at various ages were studied. In in vitro experiment, adrenal gland cells were isolated from fetal, neonatal, immature and adult rats by the method described by us before and were incubated in MEM. We chose to designate the hormones in the medium as hormone secretion. In ...

Galacomannan was isolated from Trigonella foenum graceum Linn Family: Leguminosae (TF) seeds. The objective was to study the anabolic and androgenic activity of galactomannan in immature castrated male rats and also on testicular histology in non-castrated immature rats. The rats (55± 5 g) were castrated. The rats were treated with either vehicle, testosterone (10 mg/kg s.c. bi weekly) or galac...