Innate lymphoid cells (ILCs) have now been identified within Background most tissues of the body and current evidence indicates that this family of cells play a fundamental role in maintaining tissue homeostasis. However, few studies have compared the ILC populations between several tissues. : We sought to generate a comprehensive characterisation of the ILC Methods populations in different tis...

Innate lymphoid cells (ILC) are members of a heterogeneous family with a lymphoid origin that mimics the T helper (Th) cytokine profile. ILC are involved in early effector cytokine-mediated responses during infections in peripheral tissues. ILC also play an important role in chronic skin inflammatory diseases, including psoriasis. Although classical ILC express CD127, it has been recently repor...

One in twelve American women will develop breast cancer, with infiltrating lobular carcinoma (ILC) comprising approximately 15% of these cases. The incidence of ILC has been increasing over the last several decades. It has been hypothesized that this increase is associated with combined replacement hormonal therapy. Although pathologically distinct from infiltrating ductal carcinoma (IDC), ILC ...

In recent years we have witnessed a blooming interest in innate lymphoid cell (ILC) biology thanks to the discovery of novel lineages of ILC that are phenotypically and functionally distinct from NK cells. While the importance of these novel ILC subsets as essential functional components of the early immune responses are now clearly established, many questions remain as to how early ILC develop...

PURPOSE The aims of this study were to compare the expression of sarcosine metabolism-related proteins between invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) and to determine the implications of these results. MATERIALS AND METHODS Tissue microarrays were constructed, containing 30 samples from normal breast tissue, 114 samples from patients with ILC, and 692 samples fro...

In this paper, an iterative learning control method based on the recognition, response, and memory mechanism of immune system (IRRM-ILC) is proposed. According to the immunological recognition, response, and memory processes, several new components are designed and then combined with the conventional ILC. The proposed IRRM-ILC controller can mitigate the disturbances by detecting, identifying, ...

A simple iterative learning controller (ILC) is proposed for the tracking control of uncertain discrete-time non-linear systems performing the repetitive tasks. The tracking error of the current learning iteration is utilized in the ILC updating law. It is proven that, under relaxed conditions, the nal tracking error is bounded in the presence of uncertainty, disturbance and the ini-tialization...

ERBB2 and ERBB3 somatic gain-of-function mutations, which may be targeted by anti-ERBB2 therapies, were reported by high-throughput sequencing studies in 1% and 2% of invasive breast cancers respectively. Our study aims to determine ERBB2 and ERBB3 mutations frequencies in grade 3 and/or ERBB2-positive invasive lobular breast carcinomas (ILC). All the 529 ILC surgically-excised registered at In...

A P-type iterative learning controller (ILC) which includes a current iteration tracking error (CITE) in its high-order updating law is proposed for the tracking control of repetitive uncertain discrete-time non-linear systems. It is shown that, under relaxed conditions , the tracking error bounds are class-K functions of the bounds of uncertainty, disturbance and the ini-tialization error. The...

This paper presents an experimental validation of a recently proposed robust normoptimal iterative learning control (ILC). The robust ILC input is computed by minimizing the worst-case value of a performance index under model uncertainty, yielding a convex optimization problem. The proposed robust ILC design is experimentally validated on a lab scale overhead crane system, showing the advantage...