نتایج جستجو برای: il4
تعداد نتایج: 829 فیلتر نتایج به سال:
BACKGROUND Previous studies have suggested that IL4, IL13, and IL4R are associated with serum IgE levels and allergies, and common variants of these genes may alter cancer risk. To clarify these associations, we conducted a meta-analysis to investigate the associations of IL4, IL13, and IL4R polymorphisms with gastrointestinal cancer risk. METHODS We used 27 eligible case-control studies desc...
BACKGROUND Regular exposure to tobacco smoke at home causes airway inflammation and altered cytokine regulation; however, there is variation between individuals of different countries. OBJECTIVE To determine effects of passive smoking on plasma IL4, TNFá, and CRP in healthy male school-children in Khartoum. METHODS A total of 135 male school-pupils (69 passive smokers and 66 non-smokers) we...
A single nucleotide polymorphism in the promoter of the multifunctional cytokine Interleukin 4 (IL4) affects the binding of NFAT, a key transcriptional activator of IL4 in T cells. This regulatory polymorphism influences the balance of cytokine signaling in the immune system, with important consequences-positive and negative-for human health. We determined that the NFAT binding site is unique t...
The prevalence of asthma keeps on increasing worldwide, especially in western societies over last 40 years. The mechanism of asthma is unclear. Recently, concern about indoor air pollution as a risk factor for asthma has been arisen. In present study, 25 Kun Ming male mice were placed in an air chamber containing respective formaldehyde (FA) concentration of 0, 0.5, 1.0, 3.0 mg/m3,and 3.0 mg/m3...
Allergy is inversely related to glioma risk. To determine whether prediagnostic allergy-related serum proteins are associated with glioma, we conducted a nested case-control study of seven cytokines (IL4, IL13, IL5, IL6, IL10, IFNG, TGFB2), two soluble cytokine receptors (sIL4RA, sIL13RA2) and three allergy-related transcription factors (FOXP3, STAT3, STAT6) using serum specimens from the Janus...
Pigs infected with Ascaris suum or controls were given 100 microg (low-dose) or 1,000 microg (high-dose) all-trans retinoic acid (ATRA)/kg body weight in corn oil or corn oil alone per os on days after inoculation (DAI) -1, +1, and +3 with infective eggs. Treatment with ATRA increased interleukin 4 (IL4) and IL12p70 in plasma of infected pigs at 7 DAI and augmented bronchoalveolar lavage (BAL) ...
هدف از پژوهش حاضر مطالعه اثر مکمل سازی امگا 3 در یک دوره تمرینات فزاینده بر سطوح استراحتی سایتوکاین التهابی inf? و سایتوکاین تنظیمی il4در قایقرانان مرد نخبه بود. بدین منظور 20 قایقران مرد عضو تیم ملی رشته دراگون بوت با میانگین سن 23.62 سال، قد 179.76 سانتی متر، وزن 67.72 کیلوگرم و حداکثر اکسیژن مصرفی 44.57 میلی لیتر/کیلوگرم/ دقیقه ، به عنوان آزمودنی های پژوهش به دو گروه دارونما و مکمل تقسیم شدن...
A major resource for tomato quality improvement and gene discovery is the collection of introgression lines (ILs) of cultivated Solanum lycopersicum that contain different, defined chromosomal segments derived from the wild tomato relative, S. pennellii. Among these lines, IL4-4, in which the bottom of S. lycopersicum (cv. M82) chromosome 4 is replaced by the corresponding S. pennellii segment,...
IL4, a cytokine produced mainly by immune cells, may promote the growth of epithelial tumors by mediating increased proliferation and survival. Here, we show that the type II IL4 receptor (IL4R) is expressed and activated in human breast cancer and mouse models of breast cancer. In metastatic mouse breast cancer cells, RNAi-mediated silencing of IL4Ra, a component of the IL4R, was sufficient to...
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