نتایج جستجو برای: il1rn
تعداد نتایج: 275 فیلتر نتایج به سال:
In this study we investigated the association of the interleukin-1 receptor antagonist gene variable number tandem repeat (IL1RN VNTR) polymorphism and of the inhibitor of kappa B-like protein (IKBL) gene polymorphism with myocardial infarction (MI) in a group of patients with type 2 diabetes. The IL1RN VNTR and the IKBL+ 738T > C gene polymorphisms were tested in 374 Caucasians: 151 cases with...
BACKGROUND A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. OBJECTIVE To determine whether inflammatory genetic markers could stratify patients with knee OA into high and low risk for destructive disease. METHODS Genotype associations with knee OA severity were assessed in two Caucasian populations. Fif...
Recently, polymorphisms in macrophage inhibitory cytokine-1 (MIC1) and interleukin 1 receptor antagonist (IL1RN) were identified to be associated with prostate cancer risk (1-3). MIC-1 is a divergent member of the transforming growth factor-h superfamily of cytokines. In the Cancer Prostate in Sweden study, the nonsynonymous MIC1 H6D polymorphism was associated with a lowered risk of prostate c...
OBJECTIVE Chronic obstructive pulmonary disease (COPD) is a major health problem. The disease is driven by abnormal inflammatory reactions in response to inhaled particles and fumes. Therefore, inflammatory mediators are postulated to be of distinct importance. Keeping in view of the above facts; we investigate the role of polymorphisms of cytokine genes in the genetic predisposition of COPD. ...
BACKGROUND Data on the association between the interleukin-1 (IL-1) gene polymorphisms and Graves' disease (GD) risk were conflicting. A meta-analysis was undertaken to assess this association. METHODS We searched for case-control studies investigating the association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk. We extracted data using standardized forms and ...
BACKGROUND AND PURPOSE Evidence is emerging that inflammation plays a key role in the pathophysiology of ischemic stroke (IS). The aim of this study was to investigate whether genetic variation in the interleukin-1α, interleukin-1β, and interleukin-1 receptor antagonist genes (IL1A, IL1B, and IL1RN) is associated with IS and/or any etiologic subtype of IS. METHODS Twelve tagSNPs were analyzed...
Recent studies demonstrated that interleukin 1 receptor antagonist (IL-1RN) plays an important role in metabolic effects. To investigate whether IL1RN polymorphisms are associated with obesity, two single nucleotide polymorphisms (SNPs) of the IL1RN gene [rs4251961 (-828, T> C) and rs315952 (Ser133Ser)] were analyzed in 122 overweigh/obese and 123 control subjects. Overweigh/obese subjects were...
activity of these two cytokines is neutralized. Specific alleles of the human IL1RN were found to be associated with chronic hypochlorhydric response to Helicobacter pylori infection and the risk of gastric cancer [4], and with severe clinical symptoms in several chronic inflammatory diseases, including systemic lupus erythematosus [5], ulcerative colitis [6] and alopecia areata [7]. Two SNPs w...
BACKGROUND The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. PATIENTS AND METHODS A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcino...
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