نتایج جستجو برای: il1β

تعداد نتایج: 533  

Journal: :Annals of the rheumatic diseases 2002
B Bresnihan

Interleukin 1 (IL1) plays a central part in the pathophysiology of rheumatoid arthritis (RA). 2 The IL1 gene family includes IL1α, IL1β, and IL1 receptor antagonist (IL1Ra). IL1α and IL1β are both agonist molecules. There are two distinct IL1 receptors, designated type I (IL1RI) and type II (IL1RII). IL1 binding to IL1RI results in signal transduction and cell activation. IL1Ra is the third mem...

2014
Stéphanie Backman Alexandra Kollara Robin Haw Lincoln Stein Theodore J. Brown

Studies indicate that high-grade serous ovarian carcinoma (HGSOC), the most common epithelial ovarian carcinoma histotype, originates from the fallopian tube epithelium (FTE). Risk factors for this cancer include reproductive parameters associated with lifetime ovulatory events. Ovulation is an acute inflammatory process during which the FTE is exposed to follicular fluid containing both pro- a...

Journal: :Molecular cancer therapeutics 2015
Tali Voloshin Dror Alishekevitz Limor Kaneti Valeria Miller Elina Isakov Irena Kaplanov Elena Voronov Ella Fremder Moran Benhar Marcelle Machluf Ron N Apte Yuval Shaked

Acquired resistance to therapy is a major obstacle in clinical oncology, and little is known about the contributing mechanisms of the host response to therapy. Here, we show that the proinflammatory cytokine IL1β is overexpressed in response to paclitaxel chemotherapy in macrophages, subsequently promoting the invasive properties of malignant cells. In accordance, blocking IL1β, or its receptor...

Journal: :Arquivos de neuro-psiquiatria 2011
Pedro Paulo Vasconcellos Varella Joselita Ferreira Carvalho Santiago Henrique Carrete Elisa Mieko Suemitsu Higa Elza Márcia Targas Yacubian Ricardo Silva Centeno Luís Otávio Sales Ferreira Caboclo Eduardo Ferreira de Castro Neto Mauro Canzian Débora Amado Esper Abrão Cavalheiro Maria da Graça Naffah-Mazzacoratti

We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained aft...

2016
Baris Alper Baris Erdogan Mehmet Özgür Erdogan Korkut Bozan Murat Can

We investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1β and IL6), and the serum levels of tumour necrosis factor-α (TNFα) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used as components of a new biochemical parameter-based ISS system. The levels of CRP, TNFα, IL1β, and...

Journal: :Journal of biomolecular NMR 2015
Dominic Barthelmes Markus Gränz Katja Barthelmes Karen N Allen Barbara Imperiali Thomas Prisner Harald Schwalbe

We recently engineered encodable lanthanide binding tags (LBTs) into proteins and demonstrated their applicability in Nuclear Magnetic Resonance (NMR) spectroscopy, X-ray crystallography and luminescence studies. Here, we engineered two-loop-LBTs into the model protein interleukin-1β (IL1β) and measured (1)H, (15)N-pseudocontact shifts (PCSs) by NMR spectroscopy. We determined the Δχ-tensors as...

2011
Yogesh Dahiya Rajeev Kumar Pandey Ajit Sodhi

Nod2 is a cytosolic pattern recognition receptor. It has been implicated in many inflammatory conditions. Its signaling has been suggested to modulate TLR responses in a variety of ways, yet little is known about the mechanistic details of the process. We show in this study that Nod2 knockdown mouse peritoneal macrophages secrete more IL1β than normal macrophages when stimulated with peptidogly...

2017
Leilei Zhong Stefano Schivo Xiaobin Huang Jeroen Leijten Marcel Karperien Janine N Post

Interleukin 1 beta (IL1β) and Wingless-Type MMTV Integration Site Family (WNT) signaling are major players in Osteoarthritis (OA) pathogenesis. Despite having a large functional overlap in OA onset and development, the mechanism of IL1β and WNT crosstalk has remained largely unknown. In this study, we have used a combination of computational modeling and molecular biology to reveal direct or in...

Journal: :Protein engineering, design & selection : PEDS 2014
Christian Hess Dario Neri

There is an increasing biotechnological interest in 'arming' therapeutic antibodies with bioactive payloads. Many antibody-cytokine fusion proteins (immunocytokines) have been described and some of these biopharmaceuticals have progressed to clinical studies. Here, we describe for the first time the expression and in vivo characterization of immunocytokines based on murine IL1β and IL6. These p...

Journal: :Cytokine 2013
Oliver P T Barrett Arne Yndestad Andrew K Marshall Peter H Sugden Angela Clerk

In the heart, inflammatory cytokines including interleukin (IL) 1β are implicated in regulating adaptive and maladaptive changes, whereas IL33 negatively regulates cardiomyocyte hypertrophy and promotes cardioprotection. These agonists signal through a common co-receptor but, in cardiomyocytes, IL1β more potently activates mitogen-activated protein kinases and NFκB, pathways that regulate gene ...

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