The aim of this study was to examine the anti-inflammatory effects of co-administration of growthhormone-releasing peptide-2 (GHRP-2) and growth hormone (GH) on tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) gene expression induced by LPS in the mousebrain. Thirty-five male NMRI mice (25±5 g) were injected through the mouse tail vein with saline,...

conclusions il6 and il8 gene polymorphisms have no role in nash pathogenesis and liver fibrosis process, but presence of the a/a genotype in the il8 gene is associated with disease progression. patients and methods consecutive patients with biopsy proven nash and age- and gender-matched healthy individuals with normal liver function tests and normal ultrasonography were enrolled in the study. h...

Background: Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. These changes are induced mostly by cytokines which are produced by T helper (Th) 2 cells. Recently, the role of interleukin-23 (IL-23) in the pathogenesis of adultallergic asthma has been studied. Objective: To explore IL...

Backgrounds and objectives: Interleukin 2 (IL-2) secreted by activated CD4+ T cells  has been known as a major mediator in both  adaptive and native immune system  due to a board range of effects on  different cells in the immunity system (1-6). Methods: cDNA synthesis was performed using gene- specific primers designed by Gene Runner software after RNA extraction of mouse splenocytes. PCR pro...

the aim of this study was to examine the anti-inflammatory effects of co-administration of growthhormone-releasing peptide-2 (ghrp-2) and growth hormone (gh) on tumor necrosis factor-α (tnf-α),interleukin-6 (il-6) and inducible nitric oxide synthase (inos) gene expression induced by lps in the mousebrain. thirty-five male nmri mice (25±5 g) were injected through the mouse tail vein with saline,...

The intron-exon structure of Khorasan native fowl interleukin-2 (IL-2) was investigated. For this purpose, twenty chickens were selected from the Native Fowl Breeding Station of Khorasan province, and genomic DNA was extracted using a modified conventional DNA extraction protocol. An 875 bp fragment of IL-2 was successfully amplified, including a small part of the promoter, exon 1, intron 1, an...