Of the 21 new sources that INTEGRAL discovered up to Feb. 1, 2004, 5 were detected with the BeppoSAX Wide Field Cameras at earlier times. IGR J16320-4751 appears to be a persistently active X-ray source which hints at a supergiant Roche-lobe overflowing companion star in this proposed highmass X-ray binary. IGR J17091-3624 is a transient source that was detected in 1996 and 2001 with a maximum ...

INTEGRAL monitoring of the Galactic Plane in the last 5 years revealed a new subclass of High Mass X-ray Binaries (HMXBs), the Supergiant Fast X-ray Transients (SFXTs). They display flares lasting from minutes to hours, with peak luminosity of 1036 −1037 erg s−1 and a frequent long term flaring activity reaching an X-ray luminosity of 1033 − 1034 erg s−1, as recently detected by the Swift satel...

The goal of this study was to determine the prevalence and associated risk factors of impaired glucose regulation (IGR) in the population of Tongzhou, China, and to provide scientific basis for preventive interventions. In the study, the overall age-standardized prevalence of IGR (16.0%) in Tongzhou residents was higher than that in the national population (15.0%). There was no significant geog...

Previously we have shown that insertion of IS1301 in the sia/ctr intergenic region (IGR) of serogroup C Neisseria meningitidis (MenC) isolates from Spain confers increased resistance against complement-mediated killing. Here we investigate the significance of IS1301 in the same location in N. meningitidis isolates from the UK. PCR and sequencing was used to screen a collection of more than 1500...

The intergenic region-internal ribosome entry site (IGR-IRES) of dicistroviruses binds to 40S ribosomal subunits in the absence of eukaryotic initiation factors (eIFs). Although the conserved loop sequences in dicistroviral IGR-IRES elements are protected from chemical modifications in the presence of the 40S subunit, molecular components in the 40S subunit, which interacts with the loop sequen...

Previous studies of oxytocin (OT) and vasopressin (VP) cell-specific gene expression in the hypothalamus using transgenic mouse and rat models focused attention on the intergenic region (IGR) as the site of critical enhancer elements. In this study, we used organotypic slice-explant cultures of rat hypothalamus as in vitro models, and particle-mediated gene transfer (biolistics) transfection me...

We present spectra for 34 accretion-powered X-ray and one millisecond pulsars that were within the field of view of the INTEGRAL observatory over two years (December 2002–January 2005) of its in-orbit operation and that were detected by its instruments at a statistically significant level (> 8σ in the energy range 18–60 keV). There are seven recently discovered objects of this class among the p...

BACKGROUND Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progression to diabetes. This study investigated the association between Traditional Chinese Medicine (TCM) body constitution and serum cytokines, and whether body constitution could...

OBJECTIVE Mortality among adults of all ages diagnosed with impaired glucose regulation (IGR) in Tayside, Scotland, UK, was evaluated using routinely collected healthcare data sets. RESEARCH DESIGN AND METHODS Using record-linked data in 2003-2008, all instances of blood glucose testing in the population defined 2 cohorts of patients aged 18+years: those with IGR (whether impaired fasting glu...

BACKGROUND Our previous study has recently shown that plasma heme oxygenase-1 (HO-1), a stress-responsive protein, is elevated in individuals with type 2 diabetes. The current study aimed to examine the association between plasma HO-1 concentration and impaired glucose regulation (IGR) in non-diabetic individuals. METHODS We conducted a case-control study including a total of 865 subjects (26...