Background Hyperimmunoglobulin E syndrome (HIES) is a rare desease caused by a primary complex immunodeficiency, with IgE serum levels over 2,000U/mL. The syndrome is characterized by the following triad: 1) recurrent staphylococcal abscesses, 2) recurrent airway infections; 3) elevated serum IgE concentration. Our pacient presented signs that are compatible with HIES in distinct moments of his...

Job’s syndrome, a subset of the Hyper-immunoglobulin E (IgE) recurrent Infection Syndrome (HIES), is a rare primary immunodeficiency disorder characterized by a classic clinical triad of recurrent staphylococcal abscesses, recurrent cyst-forming pneumonia, and markedly elevated serum IgE level. To date, slightly more than 200 cases have been published worldwide. Here we review HIES and report o...

BACKGROUND Anisakis simplex is a helmintic parasite of fish and shellfish that can induce in humans, after consumption, an immunoallergic response with multiorganic affectation, especially cutaneous (urticaria and angioedema), gastrointestinal and anaphylactic symptoms. Nephrotic syndrome can be produced by helmintic infection, especially schistosomiasis. OBJECTIVE To report the unusual case ...

Cultivated strawberry (Fragaria × ananassa) is a fruity vegetable of the Rosaease family and contains allergens which cause oral allergic syndrome (OAS). OAS type I allergy mediated by IgE, as symptoms appear in cavity, hypoallergenic fruits are eagerly anticipated. The major allergen Fra 1—an ortholog birch pollen Bet v 1. It necessary to understand characteristics 1 planta properly regulate a...

Kidney disease due to Aspergillus fumigatus is a rare finding in hyper-IgE syndrome. We report a patient with autosomal dominant hyper-IgE syndrome, recurrent pneumonia, and acute necrosuppurative pyelonephritis caused by Aspergillus fumigatus with a fatal outcome. We emphasize the severity and the difficulties in the management of renal complications that could be limiting the survival of thes...

Food protein induced enterocolitis syndrome (FPIES) is a food-related non-IgE-mediated gastrointestinal hypersensitivity disorder. Atypical FPIES is characterized by the presence of specific IgE for the causative food. The guidelines suggested for diagnostic oral food challenge in pediatric patients affected by suspected FPIES are different from the ones for children with IgE-mediated food alle...

Hyper IgE syndrome (HIES) is a rare immunodeficiency syndrome, with autosomal dominant inheritance, caused mainly due to STAT 3 mutation. The affected children usually present atopic dermatitis, recurrent staphylococcal infections, phenotypic characteristics and increased levels. Though, there case report of autoimmune thyroiditis in HIES, congenital hypothyroidism not reported. Here we HIES ty...