نتایج جستجو برای: ifnl4

تعداد نتایج: 81  

Journal: :journal of research in medical sciences 0
maryam keshvari seyed moayed alavian bita behnava ali pouryasin heidar sharafi

background: a dinucleotide variant rs368234815 in interferon lambda 4 (ifnl4) gene was recently found to be associated with the hepatitis c virus (hcv) treatment response. this study aimed to assess the impact of ifnl4 rs368234815 polymorphism on treatment response to pegylated?ifn alpha (peg?ifn??) and ribavirin (rbv) in hemophilic patients with chronic hepatitis c (chc). materials and methods...

2016
Karina Gonzalez-Aldaco João R. Rebello Pinho Sonia Roman Ketti Gleyzer Nora A. Fierro Leticia Oyakawa Omar Ramos-Lopez Rubia A. Ferraz Santana Roberta Sitnik Arturo Panduro David R. Booth

AIM To analyze the genetic heterogeneity of the Amerindian and admixed population (Mestizos) based on the IL28B (rs12979860, rs8099917) and IFNL4 (rs368234815) haplotypes, and their association with spontaneous clearance (SC) and liver damage in patients with hepatitis C infection from West Mexico. METHODS A total of 711 subjects from West Mexico (181 Amerindians and 530 Mestizos) were studie...

2013
Daiki Miki Hidenori Ochi Atsushi Takahashi C. Nelson Hayes Yuji Urabe Hiromi Abe Tomokazu Kawaoka Masataka Tsuge Nobuhiko Hiraga Michio Imamura Yoshiiku Kawakami Hiroshi Aikata Shoichi Takahashi Norio Akuta Fumitaka Suzuki Kenji Ikeda Hiromitsu Kumada Yoshiyasu Karino Joji Toyota Tatsuhiko Tsunoda Michiaki Kubo Naoyuki Kamatani Yusuke Nakamura Kazuaki Chayama

Hepatitis C virus (HCV) establishes a chronic infection in 70-80% of infected individuals. Many researchers have examined the effect of human leukocyte antigen (HLA) on viral persistence because of its critical role in the immune response against exposure to HCV, but almost all studies have proven to be inconclusive. To identify genetic risk factors for chronic HCV infection, we analyzed 458,20...

Journal: :hepatitis monthly 0
qin wu department of infectious diseases, west china hospital, sichuan university, chengdu, china cong wang department of nursing, west china hospital, sichuan university, chengdu, china en qiang chen department of infectious diseases, west china hospital, sichuan university, chengdu, china hong tang department of infectious diseases, west china hospital, sichuan university, chengdu, china zhen zhen li west china school of medicine, west china hospital, sichuan university, chengdu, china xue zhong lei department of infectious diseases, west china hospital, sichuan university, chengdu, china; department of infectious diseases, west china hospital, sichuan university, p. o. box: 610041, chengdu, china. tel: +86-2885423346, fax: +86-2885423052

context there is growing evidence that interferon lambda 4 (ifnl4) polymorphism is related to sustained virological response (svr) in hepatitis c virus (hcv) infection. we analyzed the relationship between ifnl4 (rs368234815) polymorphism and svr in dual- and triple- therapy in hcv genotype 1, 2, 3 and 4 infected asian, caucasian and african patients. conclusions favorable ifnl4 rs368234815 gen...

Journal: :Malaria Journal 2021

Abstract Background Interferon (IFN)- ?4, a type III IFN, production is controlled by dinucleotide frameshift variant (rs368234815-dG/TT) within the first exon of IFNL4 gene. Carriers -dG allele but not -TT are able to produce IFN-?4 protein. Patients with hepatitis C virus that do protein have higher rates viral clearance suggesting potential inhibitory role in liver-tropic infections. Methods...

2016
Mark H. Kuniholm Thomas R. O'Brien Ludmila Prokunina-Olsson Michael Augenbraun Michael Plankey Roksana Karim Monika Sarkar Audrey L. French Chris Pierce Howard D. Strickler Kathryn Anastos

BACKGROUND Recent studies reported that the CD4/CD8 T-cell ratio is inversely associated with biomarkers traditionally used to measure immune activation and systemic inflammation in highly active antiretroviral therapy-treated HIV-infected (HIV+) patients. The relation of hepatitis C virus (HCV) coinfection with the CD4/CD8 ratio in HIV+ patients is unknown. METHODS We examined 50,201 CD4/CD8...

Journal: :Wellcome open research 2021

Background: Angiotensin I converting enzyme 2 (ACE2) is a receptor for the severe acute respiratory syndrome coronavirus (SARS-CoV-2) and differences in its expression may affect susceptibility to infection. Methods: We performed genome-wide quantitative trait loci (eQTL) analysis using hepatitis C virus-infected liver tissue from ...

Journal: :hepatitis monthly 0
heidar sharafi iran hepatitis network, tehran, ir iran; middle east liver disease (meld) center, tehran, ir iran; armin pathobiology laboratory, tehran, ir iran seyed moayed alavian iran hepatitis network, tehran, ir iran; middle east liver disease (meld) center, tehran, ir iran bita behnava iran hepatitis network, tehran, ir iran; middle east liver disease (meld) center, tehran, ir iran ali pouryasin iran hepatitis network, tehran, ir iran; armin pathobiology laboratory, tehran, ir iran; department of genetics, islamic azad university-arsanjan branch, arsanjan, ir iran maryam keshvari iran hepatitis network, tehran, ir iran; middle east liver disease (meld) center, tehran, ir iran; blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran; blood transfusion research center, high institute for research and education in transfusion medicine, tehran, ir iran. tel: +98-2188601501, fax: +98-2166900386

materials and methods a case-control study was designed on 91 cases with spontaneous hcv infection clearance and 259 patients with persistent hcv infection as the control group. the rs12979860 snp was assessed as the most common ifnl polymorphism by pcr-rflp method. results distribution of rs12979860 cc genotype in the spontaneous clearance group was around two folds of its distribution in chro...

2015
Mei-Hsuan Lee Hwai-I Yang Sheng-Nan Lu Yu-Ju Lin Chin-Lan Jen Kang-Hsuan Wong Soa-Yu Chan Liang-Chun Chen Li-Yu Wang Gilbert L’Italien Yong Yuan Chien-Jen Chen

The aims of this study were to investigate associations between single nucleotide polymorphisms (SNPs) near the genes IFNL2, IFNL3, and IFNL4 and spontaneous clearance of hepatitis C virus (HCV) and to evaluate variants for their risk of hepatocellular carcinoma (HCC) among subjects in whom spontaneous HCV RNA clearance did not occur. In the first study, 889 untreated anti-HCV-seropositive pati...

2015

Objectives: Serum hepatitis C virus (HCV) core antigen (HCVcAg) concentrations correlate with HCV RNA levels in HCV monoinfected patients. Data in HCV/HIV coinfected patients are still limited. We aim to compare the use of HCVcAg measurement with respect to HIV status, HCV genotypes, interferon-lambda-4 (IFNL4) polymorphism and clinical parameters. Methods: We analyzed an untreated cohort of 10...

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