نتایج جستجو برای: ifn β

تعداد نتایج: 211090  

Journal: :Journal of immunology 2015
Ryan D Schubert Yang Hu Gaurav Kumar Spencer Szeto Peter Abraham Johannes Winderl Joel M Guthridge Gabriel Pardo Jeffrey Dunn Lawrence Steinman Robert C Axtell

IFN-β remains the most widely prescribed treatment for relapsing remitting multiple sclerosis. Despite widespread use of IFN-β, the therapeutic mechanism is still partially understood. Particularly, the clinical relevance of increased B cell activity during IFN-β treatment is unclear. In this article, we show that IFN-β pushes some B cells into a transitional, regulatory population that is a cr...

Journal: :Molecular and cellular biology 2016
Vasco Marcato Lionel Luron Lucie M Laqueuvre Dominique Simon Zeyni Mansuroglu Marie Flamand Jean-Jacques Panthier Sylvie Souès Charbel Massaad Eliette Bonnefoy

Rapid upregulation of interferon beta (IFN-β) expression following virus infection is essential to set up an efficient innate antiviral response. Biological roles related to the antiviral and immune response have also been associated with the constitutive production of IFN-β in naive cells. However, the mechanisms capable of modulating constitutive IFN-β expression in the absence of infection r...

Journal: :iranian journal of allergy, asthma and immunology 0
mohammad taheri department of medical genetics, faculty of medicine, shahid beheshti university of medical sciences, tehran, iran mohammadreza mirinezhad department of medical genetics, mashhad university of medical sciences, mashhad, iran mir davood omrani department of medical genetics, faculty of medicine, shahid beheshti university of medical sciences, tehran, iran elham sajjadi department of hematology, school of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran hidetoshi inoko department of molecular science, school of medicine, tokai university, isehara, japan and genodive pharma inc., atsugi, japan arezou sayad department of medical genetics, faculty of medicine, shahid beheshti university of medical sciences, tehran, iran

multiple sclerosis (ms) is an inflammatory, multifocal, immune-mediated disease of the central nervous system that women are at a higher risk to acquire than men. myxovirus resistance protein a (mxa) is used as a predictive marker of bioactivity of interferon-beta (ifn-β) therapy in ms patients. this study was undertaken in west of iran to investigate gender differences in the expression level ...

Journal: :Journal of virology 2014
J D Burke L C Platanias E N Fish

UNLABELLED An effective type I interferon (IFN)-mediated immune response requires the rapid expression of antiviral proteins that are necessary to inhibit viral replication and virus spread. We provide evidence that IFN-β regulates metabolic events important for the induction of a rapid antiviral response: IFN-β decreases the phosphorylation of AMP-activated protein kinase (AMPK), coincident wi...

Journal: :Acta biochimica et biophysica Sinica 2012
Hongling Huang Tian Xiao Lingfeng He Hongbin Ji Xin-Yuan Liu

Interferon-β (IFN-β) has been widely used in cancer therapy, but the clinical trial results are generally disappointing. Our previous studies have shown that an oncolytic adenovirus carrying IFN-β (ZD55-IFN-β) exhibits significant anti-tumor activities. However, the underlying mechanisms are not clear. Here we showed that ZD55-IFN-β infection-induced S-phase cell cycle arrest in a p53-dependent...

2015
Nicolas Boivin Joanie Baillargeon Prenitha Mercy Ignatius Arokia Doss Andrée-Pascale Roy Manu Rangachari

Interferon (IFN)-β is a front-line therapy for the treatment of the relapsing-remitting form of multiple sclerosis. However, its immunosuppressive mechanism of function remains incompletely understood. While it has been proposed that IFN-β suppresses the function of inflammatory myelin antigen-reactive T cells by promoting the release of immunomodulatory cytokines such as IL-27 from antigen-pre...

2013
Chung Heon Ryu Kwang Ywel Park Yun Hou Chang Hyun Jeong Seong Muk Kim Sin-Soo Jeun

Interferon-beta (IFN- β ), a well-established standard treatment for multiple sclerosis (MS), has proved to exhibit clinical efficacy. In this study, we first evaluated the therapeutic effects for MS using human bone marrow-derived mesenchymal stem cells (hBM-MSCs) as delivery vehicles with lesion-targeting capability and IFN- β as therapeutic gene. We also engineered hBM-MSCs to secret IFN- β ...

2017
Beatriz Sanz Bernardo Stephen Goodbourn Michael D Baron

Peste des petits ruminants virus (PPRV) is a morbillivirus that produces clinical disease in goats and sheep. We have studied the induction of interferon-β (IFN-β) following infection of cultured cells with wild-type and vaccine strains of PPRV, and the effects of such infection with PPRV on the induction of IFN-β through both MDA-5 and RIG-I mediated pathways. Using both reporter assays and di...

2010
Tiffany Tran Pedro Paz Sharlene Velichko Jill Cifrese Praveen Belur Ken D. Yamaguchi Karin Ku Parham Mirshahpanah Anthony T. Reder Ed Croze

We present evidence of a link between interferonβ-1b (IFN-β) and G-protein signaling by demonstrating that IFN-β can induce the expression of the negative regulator of G-protein signaling 1 (RGS1). RGS1 reduces G-protein activation and immune cell migration by interacting with heterotrimeric G-proteins and enhancing their intrinsic GTPase activity. In this study, IFN-β treatment resulted in the...

Journal: :iranian journal of pharmaceutical research 0
manuchehr dadgarnejad center of food and drug control references laboratories (cfdcrl), food and drug organization (fdo), ministry of health and medical education (moh), tehran, iran hooshmand ilka research & development department, zistdaru danesh co. ltd., no. 1462, north kargar street, tehran, iran maryam shekarchi center of food and drug control references laboratories (cfdcrl), food and drug organization (fdo), ministry of health and medical education (moh), tehran, iran nooshin adib center of food and drug control references laboratories (cfdcrl), food and drug organization (fdo), ministry of health and medical education (moh), tehran, iran mahmood alebouyeh center of food and drug control references laboratories (cfdcrl), food and drug organization (fdo), ministry of health and medical education (moh), tehran, iran nadia keypour center of food and drug control references laboratories (cfdcrl), food and drug organization (fdo), ministry of health and medical education (moh), tehran, iran

human interferons (ifns) are key cytokines secreted by immune system. they have several effects such as antiviral and anti tumors activity, activating immune cells and healing of multiple sclerosis. the type ifns present in humans are α, β and υ. ifn β is a polypeptide, normally produced by fibroblasts and seems to be more species-specific than ifn . structural properties of i fns are importan...

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