Second generation H1 antihistamines are considered first-line therapy for allergic rhinitis and chronic idiopathic urticaria, largely because of their nonsedating effects. Evaluating pharmacokinetic and pharmacodynamic parameters and clinical efficacy of a drug is important, but models to predict clinical efficacy are lacking. Receptor occupancy (RO), a predictor for human pharmacodynamics and ...

INTRODUCTION Submucoperichondrial injection of botulinum neurotoxin A (BTA) in the nasal septum is a promising therapeutic option in the treatment of persistent allergic rhinitis (AR) and non-allergic rhinitis, and is safer and more effective than intraturbinate injection in reducing clinical symptoms. MATERIALS AND METHODS Forty patients diagnosed with persistent AR or non-allergic rhinitis ...

INTRODUCTION Idiopathic acute eosinophilic pneumonia (AEP) is characterized by hypoxemia, pulmonary infiltrates and pulmonary eosinophilia. Data is limited and the purpose of this study is to better understand this disorder. METHODS A search of the computerized patient records from January 1, 1997 to October 15, 2010 for patients with suspicion of "eosinophilic pneumonia" was conducted. Inclu...

BACKGROUND Increased incidence of adenoidal tissue enlargement in children with allergic rhinitis (AR) when compared to non-atopic children had been reported. However, data with respect to the comparison of adenoidal size in children with AR and non-allergic idiopathic rhinitis (IR) is still lacking in the literature. OBJECTIVE We aimed to compare the size of the adenoid in children with AR a...

Local allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy characterized by local production of specific IgE (sIgE) antibodies, a T(H)2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response with release of inflammatory mediators (tryptase and eosinophil cationic protein). ...

Molds are eukaryotic (possessing a true nucleus) nonphotosynthetic organisms that flourish both indoors and outdoors. For humans, the link between mold exposure and asthma exacerbations, allergic rhinitis, infections, and toxicities from ingestion of mycotoxin-contaminated foods are well known. However, the cause-and-effect relationship between inhalational exposure to mold and other untoward h...

Chronic eosinophilic pneumonia (CEP) is a syndrome associated with nonspecific pulmonary and atopic manifestations, chest imaging findings suggestive of peripheral alveolar opacities, and alveolar and blood eosinophilia.1 Onset is insidious, with symptoms lasting up to 2–4 weeks. It is usually idiopathic; however, it has been associated with drugs, allergy shots, parasites, irradiation for brea...