نتایج جستجو برای: idiopathic parkinson disease
تعداد نتایج: 1538852 فیلتر نتایج به سال:
BACKGROUND Vocal rehabilitation of patients with idiopathic Parkinson disease. AIM To describe the interfering factors in the vocal rehabilitation of five individuals with Parkinson disease and to present the modifications in the oral communication. METHOD Interviews and pre and post vocal treatment assessments were carried out using the Lee Silverman Voice treatment method (LVSTO). RESUL...
Parkinson disease (PD) is a progressive neurodegenerative disorder affecting 1% of people 65 years and older.1 The core symptoms include the motor manifestations of tremor, bradykinesia, and rigidity. Asymmetric onset and response to dopaminergic therapy are typical of idiopathic PD compared with other causes of parkinsonism. As the disease progresses, postural instability, motor fluctuations, ...
Parkinson disease (PD) is a progressive neurodegenerative disorder affecting 1% of people 65 years and older.1 The core symptoms include the motor manifestations of tremor, bradykinesia, and rigidity. Asymmetric onset and response to dopaminergic therapy are typical of idiopathic PD compared with other causes of parkinsonism. As the disease progresses, postural instability, motor fluctuations, ...
The prevalence of disordered communication is particularly high in individuals diagnosed with idiopathic Parkinson disease (IPD). At least 89% of these individuals have disordered speech and voice but only 3-4% received speech treatment. LSVT (Lee Silverman Voice Treatment) is a speech and voice treatment for individuals with Parkinson disease. It is the only speech treatment with Level one sho...
BACKGROUND Two recent studies identified a mutation (p.Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease . Although additional missense variants were described, their pathogenic role yet remains inconclusive. METHODS AND RESULTS We performed the largest multi-center study to ascertain the frequency and pathogenicity of the report...
OBJECTIVE To precisely delineate clinical risk factors for conversion from idiopathic REM sleep behavior disorder (RBD) to Parkinson disease, dementia with Lewy bodies, and multiple system atrophy, in order to enable practical planning and stratification of neuroprotective trials against neurodegenerative synucleinopathy. METHODS In a 10-year prospective cohort, we tested prodromal Parkinson ...
background: parkinson’s disease (pd) is a progressive neurodegenerative disorder causing motor and non‑motor symptoms. the latter are common and include autonomic dysfunction, cognitive impairment, and sleep difficulties. many of the non‑motor aspects of pd such as sleep disturbance are more common and significantly affect the day‑to‑day activities of patients and their quality of life. the mos...
OBJECTIVE To explore the relationship between α-synuclein pathology and mitochondrial respiratory chain protein levels within single substantia nigra neurons. DESIGN We examined α-synuclein and mitochondrial protein expression in substantia nigra neurons of 8 patients with dementia with Lewy bodies, 5 patients with Parkinson disease, and 8 control subjects. Protein expression was determined u...
BACKGROUND Over 50% of persons with idiopathic REM sleep behavior disorder (RBD) will develop Parkinson disease (PD) or dementia. At present, there is no way to predict who will develop disease. Since polysomnography is performed in all patients with idiopathic RBD at diagnosis, there is an opportunity to analyze if baseline sleep variables predict eventual neurodegenerative disease. METHODS ...
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